The following definition of resistant hypertension is proposed: Provided that adherence to the regimen can be assured, hypertension should be considered resistant if the blood pressure cannot be reduced to less than 150/100 mm Hg by a rational triple drug regimen, including a diuretic, prescribed in nearly maximal doses and if the pretreatment blood pressure was greater than or equal to 180/115...

Take home message Aim for a systolic blood pressure lower than the current recommended goal of 140 mm Hg. Optimum systolic blood pressure should be targeted to 120–130 mm Hg, especially in nondiabetic hypertensive patients with significant risk factors. Advantages of aggressive treatment to levels <120 mm Hg are still unclear. Lifestyle modifications rather than initiation of antihypertensive d...

Seabirds, as long-lived top predators, accumulate contaminants such as mercury (Hg), an established endocrine disruptor. In long lived species hormonal secretion varies with age; therefore, Hg-induced endocrine disruption may be exacerbated in some age classes. Here we investigated relationships between blood total Hg and luteinizing hormone (LH, a key pituitary hormone for the onset of breedin...

The role of angiotensinogen in blood pressure control was assessed in normotensive rats by observing the changes resulting from inhibition by specific rat angiotensinogen antiserum. The antiserum decreased blood pressure in rats on normal sodium as well as sodium-free diets (respectively delta BP = -30 +/- 6 mm Hg and -42 +/- 8 mm Hg). In binephrectomized sodium-replete rats, administration of ...

This study has attempted to establish an analysis method through validation against heavy metals in the body (Pb, Cd and Hg) using ICP-MS and Gold amalgamation and find out the relevance between heavy metal and Alzheimer's disease after analyzing the distribution of heavy metal concentration (Pb, Cd and Hg) and correlations between a control group and Alzheimer's disease group. In this study, P...

BACKGROUND Hypertension-related diseases are the leading cause of morbidity and mortality in industrially developed societies. Although antihypertensive drugs are extensively used, dietary and lifestyle modifications also are effective in the treatment of patients with hypertension. One such lifestyle intervention is the use of medically supervised, water-only fasting as a safe and effective me...

Exercise training improves cardiovascular disease risk, but individual responses are highly variable. We hypothesized that common polymorphic gene variations would affect these responses. Sedentary obese hypertensive older men who had undergone exercise training were typed at the apolipoprotein (apo) E, angiotensin-converting enzyme (ACE), and lipoprotein lipase (LPL) loci. Individuals of all g...

To better understand the distribution and elimination of inorganic mercury (Hg) and cadmium (Cd) in fishes, channel catfish (Ictalurus punctatus) were administered either 6.4 micrograms/kg 203Hg as HgCl2 or 4.0 micrograms/kg 109Cd as CdCl2 via a dorsal aortic cannula. Blood, plasma, and red blood cells (RBCs) were serially sampled up to 156 (Hg) or 335 (Cd) days. The fraction of the injected do...

The role of the brain kallikrein-kinin system in the regulation of arterial blood pressure of normotensive and spontaneously hypertensive rats was evaluated. Intracerebroventricular administration of the kinin antagonist [DArg0]Hyp3-Thi5,8[DPhe7]bradykinin caused no change in mean blood pressure in Wistar-Kyoto, Sprague-Dawley, or spontaneously hypertensive rats. The antagonist proved to be ver...

Mercury (Hg) is a ubiquitous and non-essential heavy metal that highly toxic to aquatic organisms. Few studies examine Hg its effects on wild fish populations. Here, we investigated the potential of exposure large long-lived marine species conservation concern, vulnerable Atlantic Goliath Grouper Epinephelus itajara. Our objectives were (1) measure (methyl-Hg; total = combined methyl-Hg inorgan...