The way by which contact of blood with foreign surface accelerates clotting has been elucidated from the discovery of four rare disorders of blood coagulation; Hageman trait, plasma thromboplastin antecedent (PTA) deficiency, Fletcher trait, and Fitzgerald trait. Interestingly, it was unexpectedly found that Fletcher factor is plasma prekallikrein and Fitzgerald factor is high-molecular-weight ...

Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of ...

Spontaneous extradural haemorrhage may be due to neighbourhood infections, vascular malformations of the dura mater, and disorders of blood coagulation. Two cases are described here: in one, infection was present; in the other, there was a berry aneurysm of the middle meningeal artery with a small parietal dural angioma. Operation was successful in both patients.

C OMPLEX ALTERATION of blood coagulation occurs in the course of a number of systemic disorders. In contrast to the congenital defects of hemnostasis which are usually characterized by a single clotting factor deficiency, the changes which may accompany acquired disease are characteristicallv multiple. These multiple defects tend to form typical patterns which reflect the physiologic abnormalit...

BACKGROUND Recombinant factor VIIa (rFVIIa) is registered for use in haemophilia with inhibitors and other rare bleeding disorders, but has also been used in various other clinical conditions to terminate life-threatening bleeding. Underlying conditions (e.g. coagulopathy) and dosing may affect treatment efficacy. The objective of the present study was to evaluate the impact of increasing doses...

CASE REPORT An alcoholic patient with loss of vision in his right eye and a peripapillar haemorrhage, who then presented with a venous thrombosis. Blood analysis revealed hyperhomocysteinemia with coagulation parameters within the normal range. In the follow-up he developed a bilateral optic neuropathy. DISCUSSION An increase in homocysteine levels is common in alcoholics, and it has been con...

Background: Coagulation plays an important role in haemostasis. Bleeding disorders caused by deficiency of certain coagulation factors such as hemophilia and Von Willebrand disease can affect haemostasis and may endanger life. Aim: To put a focus on the aetiology, pathogenesis, methods of diagnosis and lines of management of bleeding disorders. Conclusion: Bleeding disorders usually result from...

Blood coagulation disorders have been known to be associated with cancer for many years. However, the mechanisms responsible for their relationship have not been understood. Recent work indicates that activation of the MET oncogene, which drives invasion and metastasis in cancer, can promote a cancer-associated thrombohemorrhagic syndrome that is mediated by transcriptional up-regulation of the...

During the process of normal blood coagulation prothrombin is converted into thrombin. As a result serum contains considerably less prothrombin than the plasma from which it is derived, the prothrombin having been consumed during the coagulation of the blood. In certain conditions this conversion is incomplete and much prothrombin remains in the serum. Often this is not obvious from the usual t...