We aim to assess the effectiveness of feedback-controlled resonant drift pacing as a method for low energy defibrillation. Antitachycardia pacing is the only low energy defibrillation approach to have gained clinical significance, but it is still suboptimal. Low energy defibrillation would avoid adverse side effects associated with high voltage shocks and allow the application of implantable ca...

Langendorff-perfused hearts and working hearts are established isolated heart preparation techniques that are advantageous for studying cardiac physiology and function, especially when fluorescence imaging is a key component. However, oxygen and energy requirements vary widely between isolated heart preparations. When energy supply and demand are not in harmony, such as when oxygen is not adequ...

47-year-old man with dilated cardiomyopathy, ambulatory left ventricular assist device (Heartmate II, Thoratec Corporation, Pleasanton, CA), and biventricular pacemaker/ implantable cardioverter-defibrillator (ICD) (St. Jude Medical, St Paul, MN) presented with syncope to a local hospital. He was hemodynamically stable and otherwise asymptomatic. His electrolyte panel was unremarkable. Initial ...

BACKGROUND Up to 30% of patients with heart failure do not respond to cardiac resynchronisation therapy (CRT). This may reflect placement of the coronary sinus lead in regions of slow conduction despite optimal positioning on current criteria. OBJECTIVES To characterise the effect of CRT on left ventricular activation using non-contact mapping and to examine the electrophysiological factors i...

Background: Up to 30% of patients with heart failure do not respond to cardiac resynchronisation therapy (CRT). This may reflect placement of the coronary sinus lead in regions of slow conduction despite optimal positioning on current criteria. Objectives: To characterise the effect of CRT on left ventricular activation using non-contact mapping and to examine the electrophysiological factors i...

Antitachycardia pacing (ATP) refers to the use of pacing stimulation techniques for termination of tachyarrhythmias. Such techniques can be automatically applied using implantable cardioverter defibrillators (ICDs) and offer the potential for painless termination of ventricular tachycardia (VT). Reduction in painful shocks may improve patient quality-of-life (QOL) and extend ICD pulse generator...