Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): United Hospital Medical Education and Research Committee, Background We have previously shown that optimization cardiac resynchronization therapy (CRT) nonresponders using a novel electrical dyssynchrony mapping (EDM) system significantly improves dyssynchrony, left ventricle (LV) size systolic function. Whet...

Cardiac conduction system pacing, in the form of His-Cardiac Resynchronization therapy (His-CRT), is advantageous due to its physiological nature and accompanying clinical benefits.His-CRT has not become mainstream practice, challenges such as higher procedural time, pacing thresholds varying success rates. There a paucity studies comparing His-CRT with other modalities Left Bundle Branch Paced...

Cardiac resynchronization therapy (CRT) is an important advance for the treatment of end--stage heart failure (HF). About 15-50% of HF is complicated by atrial fibrillation (AF) and associated with worsened outcomes. Meta-analyses from observational studies suggest that patients with AF derive similar benefits to CRT as patients in sinus rhythm (SR). The presence of AF, however, may interfere w...

Abstract Introduction Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by progressive fibrofatty replacement of the myocardium and ventricular arrhythmias. Biventricular (BiV) involvement may lead to failure. This study aimed investigate characteristic proteomic patterns in plasma ACM patients, correlated them with clinical outcome as well physical exercise...

To reveal patterns of input from the six semicircular canals to motoneurons of various neck muscles and their relationship to the mechanical actions of individual neck muscles, patterns of input to neck motoneurons of the longissimus and the semispinalis muscle groups were investigated in the upper cervical spinal cord of anesthetized cats. Intracellular potentials were recorded from motoneuron...

BACKGROUND Use of rate adaptive atrioventricular (AV) delay remains controversial in patients with biventricular (Biv) pacing. We hypothesized that a shortened AV delay would provide optimal diastolic filling by allowing separation of early and late diastolic filling at increased heart rate (HR) in these patients. METHODS 34 patients (75 ± 11 yrs, 24 M, LVEF 34 ± 12%) with Biv and atrial paci...

OBJECTIVES We sought to investigate the impact of left ventricular (LV) pacing site on mechanical response to cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy (ICM). BACKGROUND CRT reduces morbidity and mortality in patients with dyssynchronous LV failure; however, variability in response, particularly in ICM patients, poses ongoing challenges. Endocardial bive...