Inherited photoreceptor degenerations (IPDs) are the most genetically heterogeneous of Mendelian diseases. Many IPDs exhibit substantial phenotypic variability, but the basis is usually unknown. Mutations in MERTK cause recessive IPD phenotypes associated with the RP38 locus. We have identified a murine genetic modifier of Mertk-associated photoreceptor degeneration, the C57BL/6 (B6) allele of ...

This paper presents a cascaded classification approach for selecting head-modifier pairs with high quality from syntactically analyzed sentences. Experimental results show that the proposed approach achieved 76.11% on Fscore of selected head-modifier pairs, which was 8.54% higher than the baseline approach that using sentence length as selection criteria. In addition, compared with using the he...

Optimality arguments and modifier theory are reviewed as paradigms for the study of the evolution of recombination. Optimality criteria (such as maximization of mean fitness) may agree with results from models developed in terms of the evolution of recombination at modifier loci. Modifier models demonstrate, however, that equilibrium mean fitness can decrease during the evolution of recombinati...

Speakers often include extra information when producing referring expressions, which is inconsistent with the Maxim of Quantity (Grice, 1975). In this study, we investigated how comprehension is affected by unnecessary information. The literature is mixed: some studies have found that extra information facilitates comprehension and others reported impairments. We used an attentional-cueing para...

Keywords sports medicine, evidence-based regression analysis, effect modifier, epidemiologic, mediation analysis

The response surface methodology using the Box-Behnken design was established to describe supercritical carbon dioxide assisted extraction of phyllanthin from Phyllanthus amarus Schum and Thonn leaves prior to HPLC analysis. The effects of extraction pressure, temperature, modifier concentration and extraction time on the yield of phyllanthin were investigated. By solving the regression equatio...

The retention of aliphatic hydrocarbons with polar groups has been compared in respect to the separation selectivity changes in reversed-phase high-performance liquid chromatography with C18 stationary phase type and binary water eluent composed of methanol, acetonitrile, or tetrahydrofuran as modifiers. The changes in separation selectivity when one modifier is replaced by another in the eluen...

This paper investigates the use of machine learning algorithms to label modifier-noun compounds with a semantic relation. The attributes used as input to the learning algorithms are the web frequencies for phrases containing the modifier, noun, and a prepositional joining term. We compare and evaluate different algorithms and different joining phrases on Nastase and Szpakowicz’s (2003) dataset ...

In this paper we describe an experiment with syntactic phrase indexing for Dutch texts. We compare different choices for combining terms to form head-modifier pairs and we also investigate the effect of adding none, one, or all constituent parts of the pair as a separate index term. The results of our experiments show that using head-modifier pairs as index terms can improve both recall and pre...