نتایج جستجو برای: bisphosphonates

تعداد نتایج: 3632  

Journal: :Canadian family physician Medecin de famille canadien 2014
Jacques P Brown Suzanne Morin William Leslie Alexandra Papaioannou Angela M Cheung Kenneth S Davison David Goltzman David Arthur Hanley Anthony Hodsman Robert Josse Algis Jovaisas Angela Juby Stephanie Kaiser Andrew Karaplis David Kendler Aliya Khan Daniel Ngui Wojciech Olszynski Louis-Georges Ste-Marie Jonathan Adachi

OBJECTIVE To outline the efficacy and risks of bisphosphonate therapy for the management of osteoporosis and describe which patients might be eligible for bisphosphonate "drug holiday." QUALITY OF EVIDENCE MEDLINE (PubMed, through December 31, 2012) was used to identify relevant publications for inclusion. Most of the evidence cited is level II evidence (non-randomized, cohort, and other comp...

2014
Lorenza Scotti Andrea Arfè Antonella Zambon Luca Merlino Giovanni Corrao

OBJECTIVE Adherence with bisphosphonates therapy is generally low. Enhancing adherence with bisphosphonates would be effective in achieving the full benefits of therapy albeit a growth in the expenditure for supporting incremented drug use is expected. The cost-effectiveness of enhancing adherence with oral bisphosphonates in a large population of osteoporotic women has been assessed in the cur...

Journal: :Dental update 2011
Yazdana Arrain Tahir Masud

Bisphosphonates are effective drugs used to treat important medical conditions affecting the skeleton, such as malignancy and osteoporosis. Bisphosphonate-associated osteonecrosis of the jaw (BONJ) is a rare but painful condition that can affect quality of life. Healthcare professionals need to be aware of this potential side-effect of bisphosphonates, as well as ways to minimize its occurrence.

2016
Deepak Chellapandian Polyzois Makras Gregory Kaltsas Cor van den Bos Lamia Naccache Raajit Rampal Anne-Sophie Carret Sheila Weitzman R. Maarten Egeler Oussama Abla

BACKGROUND Bone is the most common organ of involvement in patients with Langerhans cell histiocytosis (LCH), which is often painful and associated with significant morbidity from pathological fractures. Current first-line treatments include chemotherapy and steroids that are effective but often associated with adverse effects, whereas the disease may reactivate despite an initial response to f...

Journal: :Annals of medicine 2005
Frank Rauch Francis H Glorieux

Treatment with bisphosphonates has brought significant clinical improvements for children and adolescents suffering from moderate to severe forms of osteogenesis imperfecta (OI). Benefits include decreased pain, lower fracture incidence, and better mobility. Among the various bisphosphonates, intravenous pamidronate has been studied in most detail. It is unclear whether oral bisphosphonates are...

Journal: :Journal of medicinal chemistry 2002
Michael B Martin John M Sanders Howard Kendrick Kate de Luca-Fradley Jared C Lewis Joshua S Grimley Erin M Van Brussel Jeffrey R Olsen Gary A Meints Agnieszka Burzynska Pawel Kafarski Simon L Croft Eric Oldfield

We report the results of a comparative molecular field analysis (CoMFA) investigation of the growth inhibition of the bloodstream form of Trypanosoma brucei rhodesiense trypomastigotes by bisphosphonates. A quantitative three-dimensional structure-activity relationship CoMFA model for a set of 26 bisphosphonates having a range of activity spanning approximately 3 orders of magnitude (minimum IC...

2013
Alison J. Davis Toby O. Smith Caroline B. Hing Nidhi Sofat

OBJECTIVE Osteoarthritis (OA) is the most common form of arthritis worldwide. Pain and reduced function are the main symptoms in this prevalent disease. There are currently no treatments for OA that modify disease progression; therefore analgesic drugs and joint replacement for larger joints are the standard of care. In light of several recent studies reporting the use of bisphosphonates for OA...

Journal: :CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2012
Mahyar Etminan Farzin Forooghian David Maberley

BACKGROUND There have been several published reports of inflammatory ocular adverse events, mainly uveitis and scleritis, among patients taking oral bisphosphonates. We examined the risk of these adverse events in a pharmacoepidemiologic cohort study. METHODS We conducted a retrospective cohort study involving residents of British Columbia who had visited an ophthalmologist from 2000 to 2007....

Journal: :Anticancer research 2007
Reinhard E Friedrich Felix A Blake

UNLABELLED Over the past three years, several reports have been published on jaw osteonecrosis possibly being associated with the administration of bisphosphonates. Bisphosphonates are highly active inhibitors of osteoclasts. These drugs are used for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, tumor-associated hypercalcaemia, and in the treat...

Journal: :JOP : Journal of the pancreas 2009
Mustafa Erkan Oğuz Bilgi Mesut Mutluoğlu Günalp Uzun

Dear Sir: In the March issue of JOP. Journal of the Pancreas, Smith et al. provide the first report of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a patient with pancreatic adenocarcinoma [1]. As to the greater recognition of the relationship between the use of bisphosphonates and oral osteonecrosis, new cases with different malignancies have been diagnosed as suffering from BRON...

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