A simple and ultrasensitive procedure for non-labeling detection of nucleic acids is described in this study. It is based on the photoelectrochemical detection of target nucleic acids by forming a nucleic acid/photoreporter adduct layer on an ITO electrode. The target nucleic acids were hybridized with immobilized oligonucleotide capture probes on the ITO electrode. A subsequent binding of a ph...

A redox active and electrochemiluminescent (ECL) threading bis-intercalator, consisting of two N,N'-bis(3-propyl-imidazole)-1,4,5,8-naphthalene diimides (PIND) linked by a Ru(dmbpy)2(2+) (dmbpy = 4,4'-dimethyl-2,2'-bipyridine) complex (PIND-Ru-PIND), was synthesized for the first time. Its optical, electrochemical, and ECL properties were studied. UV-vis spectrophotometric measurements indicate...

ABSTRACT A newly arising challenge in the field of nanoparticle research concerns the control and the understanding of the interparticle interactions and interparticle properties. This should allow the development of materials based on nanoparticle assemblies which represents a great opportunity to exploit nanoparticle collective properties. Although some nanoparticle networks have been reporte...

The lethality for BALB/c mice of 1,3-bis(2-chloroethyl)-1-nitrosourea, cytosine arabinoside, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, hydroxyurea, mithramycin, a polymyxin-like antibiotic (SQ 21,286), polyadenylic polyuridylic acid, procarbazine, 5-[3,3-bis(2-chloroethyl)-1-triazeno]-imidazole-4-carboxamide (TIC-mustard) or uracil arabinoside administered in combination with Escherichia co...

The title compound, C27H38ClN2+·C32H12BF24-, was synthesized by reacting the product formed from a previous reaction between 1,3-bis-(2,6-diiso-propyl-phen-yl)imidazolinium-2-carboxyl-ate (SIPrCO2), and SOCl2, with sodium tetra-kis-[3,5-bis-(tri-fluoro-meth-yl)phen-yl]borate (NaBARF). In the cation, the imidazole ring is in a half-chair conformation and the formerly carbene carbon atom is bonde...

In the two-dimensional title coordination polymer, [Zn(C(8)H(4)O(4))(C(14)H(14)N(4))](n), the Zn(II) atom adopts a distorted tetra-hedral geometry, being ligated by two O atoms from two different benzene-1,3-dicarboxyl-ate dianions and two N atoms from two symmetry-related 1,2-bis-(imidazol-1-ylmeth-yl)benzene mol-ecules. The dihedral angles between the imidazole rings and the benzene ring in t...

Single doses of 5-(3,3-dimethyl-l-triazeno)imidazole-4carboxamide (DIC), 200 to 1000 or 25 to 1000 mg/kg, injected i.p. into rats on the 11th or 12th day of pregnancy, respectively, produced dose-related malformations of the mandible, palate, brain, and limbs of fetuses examined on the 21st day of gestation. Doses of 200 to 1000 mg/kg injected on Days 9 or 10 were lethal but not teratogenic. Si...

The title compound, [Ag(C(3)H(4)N(2))(2)](2)(C(10)H(6)O(6)S(2)), exists in the form of isolated cations and anions with electrostatic inter-action between them. The Ag atom is two-coordinated by the N atoms of two crystallographically independent imidazole mol-ecules. The naphthalene-1,5-disulfonate anion is located on a crystallographic center of symmetry. The cations and anions are connected ...