The Stanley Foundation Bipolar Network (SFBN) is an international, multisite network investigating the characteristics and course of bipolar disorder. Methods (history, ratings and longitudinal follow-up) are standardized and equally applied in all 7 centres. This article describes demographics and illness characteristics of the first 152 German patients enrolled in the SFBN as well as the resu...

BACKGROUND The aim was to investigate the personality profile of bipolar disorder I and II, and healthy controls, and to study whether personality influences the course of bipolar disorder. METHODS One hundred ten patients with bipolar disorder I, 85 patients with bipolar disorder II, and 86 healthy individuals had their personality profile assessed using the Swedish universities Scales of Pe...

The essential features of bipolar affective disorder involve the cyclical occurrence of high (manic or hypomanic episodes) and low mood states. Depressive episodes in both bipolar I and II disorder are more numerous and last for longer duration than either manic or hypomanic episodes. In addition depressive episodes are associated with higher morbidity and mortality. While multiple agents, incl...

the molecular mechanisms of the fact that more than 50% of the individuals with the same genetic make up (e.g. identical twins in schizophrenia) do not show the same psychiatric phenotype remained undefined in psychiatry. this along with the failure to find responsible genes with major effects in psychiatric disorders and lack of consistency of genetic association studies led to the current una...

objective: this study aimed to assess deficits of cognitive and emotional aspects of theory of mind in patients with bipolar disorder type 1 within a remission period. methods: in this case- control study, 30 bipolar patients and 30 normal individuals were selected through purposive sampling method for the purpose of the study. then, they were matched based on their educational background and a...

linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (scz) and bipolar mood disorder (bpd) are common. numerous evidences for linkage of two diseases on chromosome 22 have been found. these findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. in the present case-control study, association ...

OBJECTIVE Lithium remains a first-line treatment for bipolar disorder, but the mechanisms by which it prevents the recurrence of mood episodes are not known. The authors utilized data from a genomewide association study to examine associations between single nucleotide polymorphisms (SNPs) and the outcome of lithium treatment in two cohorts of patients with bipolar I disorder or bipolar II diso...

objective: this study aimed to evaluate the non-compliance rate in patients with bipolar i disorder (bid). methods: the patients admitted to iran psychiatric hospital who were diagnosed as a case of the first episode mania of bipolar i disorder (dsm-iv-tr) by 2 psychiatrists followed by one of them in a longitudinal, prospective and naturalistic study. in the follow-up early non-compliance/irre...

this study was designed to determine the prevalence of bipolar disorder in women with polycystic ovarian syndrome (pco). one hundred and ten women with definite diagnosis of pco and one hundred and ten age-matched infertile women due to other reasons except for pco were enrolled in this case-control study. ten ml fasting venous blood sample obtained to measure fasting glucose, lh and fsh. heigh...

This MRI study examined the morphology of the olfactory sulcus, a potential marker of early neurodevelopment in 26 patients with bipolar I disorder and 24 matched controls. Bipolar patients had significantly shallower olfactory sulci bilaterally compared to controls, suggesting that neurodevelopmental abnormalities contribute to the neurobiology of bipolar disorder.