Proteins on biomicroelectromechanical systems (BioMEMS) confer specific molecular functionalities. In planar FET sensors (field-effect transistors, a class of devices whose protein-sensing capabilities we demonstrated in physiological buffers), interfacial proteins are analyte receptors, determining sensor molecular recognition specificity. Receptors are bound to the FET through a polymeric int...

Statistical experimental design was used to optimize the conditions viz. Ethanol, Ammonium phosphate and Biotin concentration of L-Glutamic acid from Brevibacterium roseum NCIM 2238 by submerged fermentation. Maximum L-Glutamic acid concentration of 53.01621 g/l was obtained. The optimum conditions were found to be ethanol concentration of 5.3646 %v/v, ammonium phosphate of 0.7081 %w/v and biot...

11 11.1 Introduction The aim of the National Cancer Institute is to eliminate death and suffering from cancer by 2015, by harnessing the power of nanotechnology to provide new tools for diagnosing, imaging and treating cancer. Funded research projects include the design and fabrication of multifunctional nanodevices which promise to change the way we pinpoint cancer and deliver anticancer drugs...

It is well known that Paramecium species including green paramecia (Paramecium bursaria) migrate towards the anode when exposed to an electric field in a medium. This type of a cellular movement is known as galvanotaxis. Our previous study revealed that an electric stimulus given to P bursaria is converted to a galvanotactic cellular movement by involvement of T-type calcium channel on the plas...

In this work, a new MEMS technology for hot embossing using polydimethylsiloxane (PDMS) tools is developed and characterized. The developed technology will permit low cost, simple, and rapid fabrication of disposable microfluidic biochips and plastic microstructures for numerous BioMEMS applications. For traditional planar systems, a negative photoepoxy (SU-8) or thick positive photoresist (AZ4...

During the past five years, significant progress has been made in the development and application of micron-resolution Particle Image Velocimetry (μPIV). Developments of the technique have extended typical spatial resolutions of PIV from order 1-mm to order 1-μm. These advancements have been obtained as a result of novel improvements in instrument hardware and post processing software. Theory d...

INTRODUCTION Ocular targeted therapy has enormously been advanced by implementation of new methods of drug delivery and targeting using implantable drug delivery systems (DDSs) or devices (DDDs), stimuli-responsive advanced biomaterials, multimodal nanomedicines, cell therapy modalities and medical bioMEMs. These technologies tackle several ocular diseases such as inflammation-based diseases (e...

This paper proposes a Micro-electro-mechanical (MEMS) capacitive pressure sensor that relies on the movable electrode displaced like a flat plate equal to the maximum center deflection of diaphragm. The diaphragm, movable electrode and mechanical coupling are made of polysilicon, gold and Si3N4, respectively. The fixed electrode is gold and the substrate is Pyrex glass. This proposed method inc...

Polydimethylsiloxane (PDMS) silicone elastomer is extensively used in soft lithography processes to fabricate microscale or nano scale systems for microfluidic or cell culture applications. Though PDMS is biocompatible, it is not an ideal material for cell culture due to its poor cell adhesion properties. In this study, PDMS surfaces were modified to promote intestinal cell adhesion, in the int...

BACKGROUND The interest in introducing ecologically-clean, and efficient enzymes into modern industry has been growing steadily. However, difficulties associated with controlling their orientation, and maintaining their selectivity and reactivity is still a significant obstacle. We have developed precise immobilization of biomolecules, while retaining their native functionality, and report a ne...