charcot-marie-tooth (cmt) diseases represent a heterogeneous genetic disorder with more than 80 genes implicated, however sharing a similar phenotype. in recent years, advances in molecular genetics and molecular biology, and also the development of various animal models of cmt, have led to a better understanding. this knowledge represents a prerequisite for the development of future therapies ...

results the command is addpred for logistic regression models. conclusions the stata package provided herein can encourage the use of novel methods in examining predictive capacity of ever-emerging plethora of novel biomarkers. materials and methods we have written a stata command that is intended to help researchers obtain cut point-free and cut point-based net reclassification improvement ind...

objective: during the past decade, the importance of biomarker discovery has been highlighted in many aspects of cancer research. biomarkers may have a role in early detection of cancer, prognosis and survival evaluation as well as drug response. cancer-testis antigens (ctas) have gained attention as cancer biomarkers because of their expression in a wide variety of tumors and restricted expres...

background: numerous studies used microarray gene expression data to extract metastasis-driving gene signatures for the prediction of breast cancer relapse. however, the accuracy and generality of the previously introduced biomarkers are not acceptable for reliable usage in independent datasets. this inadequacy is attributed to ignoring gene interactions by simple feature selection methods, due...

The effects of Ocimum basilicum (O. basilicum) and its constituent, rosmarinic acid, on total and differential blood WBC, serum levels of NO2, NO3, MDA, thiol, SOD and CAT in sensitized rats were examined. The study was performed in control animals (group C) and eight groups of sensitized rats to ovalbumin which were given drinking water alone (group S), drinking water containing three concentr...

Cancer is the one of most prevalent and leading causes of death in the world. Current ad­vancements in technology improve the understanding of the pathogenesis and pathology of cancers. But, due to enlarging mortality rates, poor prognosis, and lacunae in clinical early predictive biomarkers provide an important momentum to investigate novel early diagnos­tic/prognostic markers and spec...