Scientific publishing has undergone massive change in the past two decades, and the landscape is shifting. The Journal of Biological Chemistry (JBC) must respond to this changing landscape, weighing what to preserve, what to emphasize, and how to be the best journal for a broad authorship/readership from across the globe. Simultaneously, we are witnessing truly stunning scientific advances and ...

What is the difference between “biological chemistry” and “chemical biology?” One of us (J. M. G.) received his Ph.D. at an institution where the biochemistry building was called the Laboratory of Chemical Biology, but that was a long time ago, and things have changed. Biological chemistry (or biochemistry), that is the study of life processes at the molecular level, is now quite distinct from ...

Many experiments have now shown that double helical DNA can serve as a conduit for efficient charge transport (CT) reactions over long distances in vitro. These results prompt the consideration of biological roles for DNA-mediated CT. DNA CT has been demonstrated to occur in biologically relevant environments such as within the mitochondria and nuclei of HeLa cells as well as in isolated nucleo...

Osmotic pressure technique has been employed to investigate the polymerization of bovine cw,-casein B under different experimental conditions. Results at neutral pH indicate that the polymerization of a,-casein B depends much more on ionic strength than on temperature. The number average molecular weight of a,-casein B in 0.01 M KCI, pH 7, at 20” was found to be 29,400 which corresponds to the ...

The Chemistry and Biological Significance of ThiaSpecial Articles: min: DR. ROBERT R. WILLIAMS .................... 559 Anaphylaxis in the Liverless Dog and Observations Dedication of the Crellin Laboratory of Chemistry on the Anticoagulant of Anaphylactic Shock: DES. at the California Institute of Technology: E. T. WATERS, J. MARKOWITz and L. B. JAQUES. The Future of the Laboratory: DR. LINUS ...

ing read in many parts of the book. Lastly, the topic is extremely broad and could have focused on smaller segments of PI3K signaling or on one effector, etc. As a common interest book, the book lacks focus and direction, but it does contain a large wealth of data and information that might be useful as a review or reference to the researcher interested in PI3K signaling or cell cycle regulatio...

The creation of the Earth has been extensively studied from a physical and biological standpoint. However, the knowledge of the chemistry behind the biological big bang is currently limited, with few publications in that area. Given the estimated creation time of the major oceans (10 years), it is impossible to accurately predict the most frequent chemical reactions that aided with the formatio...

Cobaltohemoglobin A binds oxygen cooperatively with a Hill coefficient of up to 2.3 and its ~1~2 is found to be 91 mm. Its oxygen afllnity is controlled by diphosphoglycerate which the protein binds very strongly. Cobaltohemoglobin A possesses only 40% of the alkaline Bohr effect of the native enzyme; carbon dioxide has no effect upon oxygen binding. The oxidation-reduction potential of cobalto...

HE ESSENTIAL role of intracellular folates in ef-T fecting one-carbon transfers in critical enzyme systems for DNA synthesis is well This has led to extensive application of various synthetic folate analogues as therapeutic and investigative tools in a variety of infectious, immunologic, and neoplastic diseases, as well as in developmental, transplantation, and tumor b i o l ~ g y. ~ , ~ While ...