Mucoadhesive controlled-release devices can improve the effectiveness of a drug by maintaining the drug concentration between the effective and toxic levels, inhibiting the dilution of the drug in the body fluids, and allowing targeting and localization of a drug at a specific site. Acrylic-based hydrogels have been used extensively as mucoadhesive systems. They are well suited for bioadhesion ...

This paper presents a facile method to fabricate bioinspired polyethylene terephthalate (PET) nanocone arrays via colloidal lithography. The aspect ratio (AR) of the nanocones can be finely modulated ranging from 1 to 6 by regulating the etching time. The samples with the AR value of 6 can present underwater superoleophobicity with the underwater oil contact angle (OCA) of 171.8°. The as-prepar...

The present in situ study investigated the influence of a preparation containing CPP/ACP (caseinphosphopeptide-amorphous calcium phosphate) (GC Tooth mousse) on initial bacterial colonization of enamel and dentin. Therefore, pellicle formation was performed in situ on bovine enamel and dentin specimens fixed to individual upper jaw splints worn by 8 subjects. After 1 min of pellicle formation G...

Dopamine mimics the exceptional moisture-resistant adhesive properties of the amino acid, DOPA, found in adhesive proteins secreted by marine mussels. The catechol side chain of dopamine was functionalized with a nitro-group, and the effect of the electron withdrawing group modification on the cross-linking chemistry and bioadhesive properties of the adhesive moiety was evaluated. Both nitrodop...

Microspheres are multiparticulate drug delivery systems that designed to deliver drugs a particular location at fixed rate. free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 1000µm. Benefits the use microspheres in fields such as delivery, bone tissue manufacturing, and absorption desorption contaminants by regeneration. The study sh...

Stimuli-sensitive biomaterials that are activated by light in need of formulations stable under indoor lighting yet can be direct sunlight. Carbene-based bioadhesives a new generation film-forming polymers rapidly with low-energy UVA light, but have never been evaluated sunlight exposure. Previous investigations evolved two flexible carbene-based platforms, where aryl-diazirine is grafted on to...

Barnacles are convenient model organisms to study both biomineralization and bioadhesion phenomena. They secrete a proteinaceous adhesive from cement proteins (CPs) strongly attach solid immersed substrates. More recently, it has been suggested that some CPs also play key role in regulating the calcification of barnacles’ protective shells. In this study, combining solution solid-state NMR spec...

The aim of this study was to prepare a new microsphere (fucosphere) system based on polyion complexation of fucoidan with chitosan, and to evaluate its treatment efficiency on dermal burns. The physicochemical properties such as mean particle size and distribution, zeta potential and bioadhesive properties of the microspheres were investigated. The formulation which had the high surface charge,...