Abstract Spent coffee grounds (SCGs) have been extensively investigated as a feedstock to produce fuels, specialty chemicals and materials. Whilst few reports used cascade processes generate several products from SCG, this work takes the novel approach of using integrated subcritical water extraction (SWE) hydrothermal carbonisation (HTC) derive three products: bioactive extract, protein isolat...

Bioactive peptides are generated during milk fermentation or enzymatic hydrolysis. Lactobacillus (L) helveticus is commonly used to produce some types of fermented products. Fermented derived bioactive known be beneficial in human health. Anti-hypertensive play a dual role the regulation hypertension through production vasoconstrictor angiotensin II and its inactivation vasodilator bradykinin. ...

It is extremely difficult to realize two conflicting properties-high hardness and toughness-in one material. Nano-polycrystalline stishovite, recently synthesized from Earth-abundant silica glass, proved to be a super-hard, ultra-tough material, which could provide sustainable supply of high-performance ceramics. Our quantum molecular dynamics simulations show that stishovite amorphizes rapidly...

the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...

Antibiotics are metabolic by-products of complex biosynthetic pathways in microorganisms. They are usually produced by aerobic spore-forming bacteria in the genera Bacillus and Streptomyces and in the Fungi Penicillium and Cephalosporium. Antimicrobials such as bacteriocins are inhibitory peptides or proteins, which have bactericidal effects on micro-organisms closely related to the producer. T...

Extracellular vesicles (EVs) are widely studied as a system of intercellular communication, as markers of various diseases, as well as a vehicle for delivery of various bioactive molecules to various cells. Investigation of EVs' structure and function requires their isolation and precise quantification. However, in the current literature, there are significant discrepancies in the estimated num...

BACKGROUND Antioxidant and chelating activities were determined in protein hydrolysates that were produced by treating a protein isolate of a non-toxic genotype of Jatropha curcas with the protease preparation alcalase. RESULTS 50 min protein hydrolysate with a degree of hydrolysis of 31.7% showed highest antioxidant and chelating activity. These activities were also determined in six peptidi...

In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was co...

Apium graveolens Linn. (Karafs) is used in traditional medicine for the treatment of the various ailments. There is a need to explore and authenticate the pharmacological profile and medicinal importance of the Karafs. In this paper, the literature and the published work on Apium were collected using online resources "Google scholar", "Web of science", "Scopus" and "PubMed". Each of the pharmac...