OBJECTIVES To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. METHODS We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out lea...

The contents of ferulic acid, senkyunolide A, butylidenephthalide, ligustilide, and n-butylphthalide were determined by UPLC analytical method; the correlation among the grade, average weight, and content was explored by correlation analysis and analysis of variance (ANOVA); the different commercial grades with average weight and content were revealed by principal component analysis (PCA) and t...

Piper betle L., more commonly known as betel or local name of Sirih, belongs to the family Piperaceae. Previous researches had shown that the leaves of P. betle possess tremendous beneficial effects including antimicrobial, antioxidant, anti-diabetic, wound healing and gastro-protective properties. This is due to the present of the two bioactive component; propenylphenols; which is the Hydroxyc...

The ability to design artificial extracellular matrices as cell-instructive scaffolds has opened the door to technologies capable of studying the fate of cells in vitro and to guiding tissue repair in vivo. One main component of the design of artificial extracellular matrices is the incorporation of biochemical cues to guide cell phenotype and multicellular organization. The extracellular matri...

A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are invol...

Background: Bioactive compounds need to resist food processing, be released from the matrix, and bioaccessible in gastrointestinal tract order provide health benefits. isolated peach pomace (PP) were encapsulated using four different wall materials improve their stability evaluate effects of vitro digestion, as well chemometric modeling among obtained encapsulates. Methods: Phenolics carotenoid...