Software reuse is commonly used to leverage existing assets and to reduce development cost and time. Reuse can be accomplished by several different mechanisms. This paper describes these mechanisms and proposes a classification framework for them. The framework has two dimensions: retest scope⎯how the reuse impacts the need for testing⎯and binding time⎯when the reuse is realized. By examining t...

The theory of nominal sets is a rich mathematical framework for studying syntax and variable binding. Within it, we can describe several binding disciplines and derive convenient reasoning principles that are compatible with u�-equivalence. In this article, we introduce the notion of binding operator, a novel construction on nominal sets that unifies and generalizes the many forms of binding pr...

The interactions of large molecules with surfaces and with each other are strongly dependent upon their surface, rather than their bulk properties. In addition, the local properties of biomolecular surfaces are very important in their own right in biomedicine and other areas, for example for locating binding sites. Following to previous work, we have developed a program to compute to compute am...

The fact that individual protein subunits must have different regions in contact with neighboring subunits in any oligomeric assembly greater than a diier is considered in relation to the nature of subunit interactions. Binding equations for this model have been derived for various different tetrameric arrangements and compared with the equations given by other models. Methods of distinguishing...

The clinical use of platinum(II)-based drugs incurs serious side effects due to the non-specific reactions with both malignant and normal cells. To circumvent such major drawback, novel metallodrugs might be combined with suitable carrier molecules, as antibodies, to ensure selective attacks on tumors while sparing healthy tissues. In this contribution, we investigate the stability of a novel P...

Deception is frequently used in cyber attacks. Detecting deception is always a challenge, as witnessed in attacks in social media and other online environments. Contexts can help to identify deception. Unfortunately, there is not much literature available in this aspect. This paper explores the unique properties of contextual binding. It examines roles that it plays. It also proposes a novel ap...

one of the most important targets in alzheimer disease is beta site amyloid precursor protein cleaving enzyme-1 (bace-1). it is a membrane associated protein and is one of the main enzymes responsible for amyloid β (aβ) production. up to now, a considerable number of peptidic and non-peptidic inhibitors of bace-1 have been developed. recently, small molecule bace-1 inhibitors have attracted the...