Introduction: The overexpression of ATP-binding cassette (ABC) transporters, ABCB1 and ABCG2, are two the major mediators multidrug resistance (MDR) in cancers. Although multiple ABCG2 inhibitors have been developed some undergone evaluation clinical trials, none clinically approved. compound, MK-2206, an inhibitor protein kinases AKT1/2/3, is undergoing trials for treatment certain types cance...