the binding energy and thermodynamic parameters of cis- platinum di ammino chlorine (cis-[pt(nh3)2cl]+) and trans- platinum di ammino chlorine (trans- [pt(nh3)2cl]+) complexes withguanine has been studied by density functional theory (dft) calculations in water. the bindingenergies (ebin) of cis- and trans-[pt(nh3)2clg]+ are calculated to be 79.38 kcal/mol and 74.98kcal/mol, respectively. the b...

the aim of this investigation was conducted to proteomic analysis of plasma obtained from pregnant women who destined to develop late-onset preeclampsia without intrauterine growth restriction (iugr) during 16 th week of gestation. plasma was obtained from primiparous women during 16 th week of gestation. 2-de proteomic analysis was done for plasma from 11 healthy pregnant women and 11 women wh...

background one disadvantage of expressing heterologous proteins in escherichia coli is that the proteins are frequently expressed as insoluble inclusion bodies. to avoid this problem, heterologous proteins are typically expressed as a fusion protein. maltose binding protein (mbp) is one of the widely used partners for production of recombinant fusion proteins in e. coli. mbp is among the most e...

conclusions the results of the present study indicate the presence of the pvl and fnb genes in the strains of s. aureus isolated from clinical specimens collected from the patients admitted to teaching hospitals in qazvin. considering the clinical significance of these organisms, and their potential in threatening public health systems, the identification, treatment, and infection control manag...

background: dna damage is one of the major consequences of radiation exposure onto the biological systems. a series of compounds including flavanoids were found to render dna protection against radiation damage. in this study we elucidated the potential of rutin and rutin hydrate to protect plasmid dna against damage induced by irradiation. materials and methods: dpph and hydroxyl radical scave...

objective: to evaluate the relationship between serum level of testosterone and sex hormone-binding globulin in men with type 2 diabetes. materials and methods: in this case-control study, forty men aged 40-70 with type 2 diabetes mellitus were randomly selected and compared with 40 non-diabetic men. the two groups were matched for their age and bmi. after complete observation and examination, ...

the antidiuretic effect of arginine vasopressin (avp) is mediated by the vasopressin v2 receptor. the docking study of avp as a ligand to v2 receptor helps in identifying important amino acid residues that might be involved in avp binding for predicting the lowest free energy state of the protein complex. whereas previous researchers were not able to detect the exact site of the ligand-receptor...

this study describes the synthesis of molecularly imprinted polymers (mips) by using an anti-che ops, namely dursban, as a template. non-covalent bulk polymerization was successfully applied to synthesis different imprinted and non-imprinted polymers with maa, mma, aa, and 4-vpy as monomer in selected porogens (chloroform, toluene, and acetonitrile). in order to evaluate the template binding of...

AbstractInteraction of Ni complex(Salen= N, N´-ethylene bis(salicylideneimine)) with hen egg-white lysozyme (HEWL) was studied by absorption spectroscopy, competitive binding study and thermal denaturation study. The protein binding affinity of Ni complex was found to be (3.0×103M−1). The binding plot obtained from the absorption titration data gives a binding constant of 2.4 (± 0.3)×103 M...