The current economic difficulties have affected most practitioners within the industry and, as a result, many firms and contractors are bidding for fewer projects, resulting in below-cost tenders. It is clear that, many firms and contractors are now operating on thin margins; which makes it increasingly difficult for them to commit to the introduction of new software applications and system upg...

The major focus of this paper is to identify the advantages, challenges and usability of BIM during the project life cycle. Understanding the actual advantages of BIM is an essential driver for effective adaptation while both academic research and case studies particularly within construction and post construction stages failed to analyse and quantify BIM benefits. It was also found there is la...

In recent decades, Building Information Modeling (BIM) is well-known and has been widely accepted by AEC industry since it could make less mistakes, conflicts, and bring more profits as well as improve the level of communication and coordination. However, in the Operation and Maintenance phase, most of the owners including the transit agencies, still lack the knowledge about what BIM deliverabl...

A selective medium, Clostridium butyricum isolation medium (BIM), is described for the isolation of C. butyricum from human feces. The BIM is a synthetic minimal medium and contains trimethoprim (16 micrograms/ml), D-cycloserine (10 micrograms/ml), and polymyxin B sulfate (20 micrograms/ml) as selective inhibitory agents. Qualitative tests indicated that C. butyricum and other butyric acid-prod...

Studies in Bim-deficient mice have shown that the proapoptotic molecule Bim plays a key role in the control of B cell homeostasis and activation. However, the role of Bim in human B lymphocyte apoptosis is unknown. We show in this study that, depending on the degree of cross-linking, B cell receptors can mediate both Bim-dependent and apparent Bim-independent apoptotic pathways. Cross-linked an...

While Building Information Modelling (BIM) is considered to be highly beneficial for managing construction projects over initiation to completion phases, the perception among the professionals is quite diverse especially in the Australian Construction context. Such a diverse viewpoint is due to lack of objective analysis of cost versus benefits and as a result the decision on up taking the BIM ...

Building Information Modeling (BIM) has recently attained widespread attention in the Architectural, Engineering and Construction (AEC) industry. BIM represents the development and use of computer-generated n-dimensional (n-D) models to simulate the planning, design, construction and operation of a facility. It helps architects, engineers and constructors to visualize what is to be built in sim...

Gastrin releasing peptide (GRP), the human homologue of bombesin (BN), is an autocrine growth factor for small cell lung cancer (SCLC) cells. The synthetic octapeptides [D-cpa1-beta-Leu8-des-Met9]litorin (BIM 26182) and [D-Phe6-Leu13-CH2NH-Cpa14]bombesin(6-14)NH2 (BIM 26189) are potent GRP/BN antagonists of the proliferation of 3T3 and rat pancreas cells. The effect of these analogues on the pr...

Chlamydia are obligate intracellular bacteria that replicate in a vacuole inside a host cell. Chlamydial infection has been shown to protect the host cell against apoptotic stimuli. This is likely important for the ability of Chlamydia to reproduce in human cells. Here we show that resistance to apoptosis is conveyed by the destruction of the proapoptotic BH3-only proteins Bim/Bod, Puma, and Ba...

The stimulatory effects of ghrelin, a 28-AA acylated peptide originally isolated from stomach, on growth hormone (GH) secretion and feeding are exclusively mediated through the growth hormone secretagogue 1a receptor (GHS-R1a), the only ghrelin receptor described so far. Several GHS-R1a agonists and antagonists have been developed to treat metabolic or nutritional disorders but their mechanisms...