Received: December 02, 2016; Accepted: December 21, 2016; Published: December 23, 2016 Intestinal bile salts are bio-surfactants existing in the gastrointestinal tract (GIT) which have essential role either on fat and lipid digestion or absorption [1]. Acidic lipases, which are secreted by the gastric chief cells in the fundic mucosa of the stomach, regulate10-30% of the lipid hydrolysis. In th...

Candida albicans is a dimorphic fungus that colonizes human mucosal surfaces with the potential to cause life-threatening invasive candidiasis. Studies on systemic candidiasis in a murine infection model using in vivo real-time bioluminescence imaging revealed persistence of C. albicans in the gall bladder under antifungal therapy. Preliminary analyses showed that bile conferred resistance agai...

Aryl(alkynyl)iodonium salts have been demonstrated to be valuable precursors to a diverse range of heteroaromatic ring systems including aryl[1,2-a]imidazopyridines. Successful application, using the recently described aryl(alkynyl)iodonium trifluoroacetate salts, is described, highlighting for the first time that the regioselectivity of this process is both counter-ion and concentration depend...

A new self-folding cavitand has been assembled through metal coordination to give a thermodynamically stable ditopic receptor of nanosize dimensions which has been used in the reversible binding of di-alkylammonium and n-alkylammonium salts.

A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increa...

BACKGROUND Multidrug resistance-associated protein 1 (MRP1 or ABCC1) -mediated transport is an important mechanism in multidrug resistance during cancer treatment. One strategy for the reversal of MRP1-mediated multidrug resistance is inhibition of this efflux pump. Therefore, efficient inhibitors are searched for and the structure-activity relationships of inhibitors are studied. In the presen...

KNOEBEL, LEON K. Intestinal absorption in vivo of micellar and nonmicellar Zipid. Am. J. Physiol. 223(2) : 255-261. 1972.-Lymphatic transport of absorbed fatty acid and rate and site of uptake from intestinal lumen were measured in bile-fistula rats which received the lipid mixture, 10 mM oleic acid and 10 mM monoolein, by steady intraduodenal infusion. The concentration of fatty acid solubiliz...

Sodeman, Thomas, Steven F. Bronk, Patricia J. Roberts, Hideyuki Miyoshi, and Gregory J. Gores. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas. Am J Physiol Gastrointest Liver Physiol 278: G992–G999, 2000.—Toxic bile salts induce hepatocyte apoptosis by a Fas-dependent, Fas ligand-independent mechanism. To account for this observation, we formulated the hyp...

THESE EXPERIMENTS SUGGEST THE FOLLOWING CONCLUSIONS CONCERNING HEMOLYTIC ACTION: 1. It is probably the proteid part of the serum which inhibits the bile salts. 2. The cholalic acid group is the active part of the bile salt molecule. 3. The protection afforded by bile salts against serum is of especial interest from the following considerations: (a) The protective action is a property apparently...

To better understand the full extent of the odorant detection capabilities of fish, we investigated the olfactory sensitivity of zebrafish to a monoamine and several polyamines using electrophysiological and activity-dependent labeling techniques. Electro-olfactogram (EOG) recording methods established the relative stimulatory effectiveness of these odorants as: spermine >> spermidine approxima...