We report an unusual case of solitary osteolytic tibial metastasis from a primary endometrial cancer in a 62-year-old woman. The primary cancer was treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy combined with postoperative external beam radiotherapy, while the tibial metastasis was treated with an above knee amputation. The rarity of the case lies on the fact that...

The oral anticoagulant dabigatran etexilate can be a challenge when patients need acute surgery. Sepsis and acute renal failure exacerbate the anticoagulant effect. There is no specific reversal agent for dabigatran etexilate, but it can be removed by hemodialysis. We present a case where a patient treated with dabigatran etexilate was admitted to intensive care unit with severe sepsis and acut...

Knee dislocations are a relatively uncommon occurrence in the trauma patient. However, sequelae may be disastrous if this condition and its complications are not recognized early. Perhaps the most significant complication is popliteal artery injury, occurring in 10-32% of knee dislocations (1). This frequent complication can result in amputation (3,6,16). Popliteal artery injury from knee dislo...

The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists altered RA signaling. Simultaneous proximo-distal and antero-posterior limb dupli...

OBJECTIVE To determine patient-, treatment-, and facility-level characteristics associated with receiving outpatient rehabilitation services after lower extremity amputation within the Veterans Affairs (VA) system. DESIGN Observational study. SETTING All Veterans Affairs Medical Centers (VAMCs). PARTICIPANTS Veterans (N=4165) with lower extremity amputation discharged from VAMCs between O...

BACKGROUND Damage to the right parietal lobe has long been associated with various disorders of body image. The authors have recently suggested that an unusual behavioural condition in which otherwise rational individuals desire the amputation of a healthy limb might also arise from right parietal dysfunction. METHODS Four subjects who desired the amputation of healthy legs (two right, one le...