We investigated the p53 status and the ability of exogenous wildtype (wt) p53 to affect chemosensitivity in three anaplastic thyroid carcinoma cell lines (BHT-101, SW-1736, and KAT-4). All three cell lines had nonfunctional p53. Treatment with mitomycin C or adriamycin did not result in accumulation of p53 or induction of p21WAF1/CIP1 or Mdm-2 and did not cause Rb dephosphorylation. BHT-101 and...

A new series of multipotent antioxidants (MPAOs), namely Schiff base-1,2,4-triazoles attached to the oxygen-derived free radical scavenging moiety butylated hydroxytoluene (BHT) were designed and subsequently synthesized. The structure-activity relationship (SAR) of the designed antioxidants was established alongside the prediction of activity spectra for substances (PASS). The antioxidant acti...

Antioxidants improve endothelial function in hypercholesterolemia (HC); however, whether this includes improvement of the vascular smooth muscle response to NO is unknown. NO relaxes arteries, in part, by stimulating Ca(2+) uptake via sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) in aortic smooth muscle, and HC impairs SERCA function and the response to NO. HC induces oxidative stress, whic...

Quinoids, quinoid radicals and phenoxyl radicals formed from estrogens (estrone; diethylstilbestrol, DES) and antiestrogens (tamoxifen; toremifene) may be responsible for adverse effects such as carcinogenesis. The radical-scavenging activity of estrogens and antiestrogens was determined quantitatively by the induction period method for the polymerization of methyl methacrylate initiated by the...

Introduction: Butylated hydroxytoluene (BHT 2, 6-di-tert-butyl-p-cresol) is one of the extensively used antioxidants in the food industry. It is used in low-fat foods, fish products, packaging materials, paraffin, and mineral oils. BHT is also widely used in combination with other antioxidants such as BHA, propyl gallate, and citric acid for the stabilization of oils and high-fat foods. On t...

In this work, a new and natural food product, stalked barnacle (Pollicipes Pollicipes) pâté enriched with blackberry, was developed to valorise the rejected barnacle. To evaluate addition of blackberry fruits (Rubus ulmifolius Schott.) as preservative on quality, four sample groups were considered: negative control without synthetic additive (CTR), positive butylated hydroxytoluene (BHT), group...

We explored in 51 normal subjects, distributed in various series of experiments, whether endothelium nitric oxide may play a role in insulin modulation of a 2 and b -adrenergic– evoked vascular responses. In particular, we examined the forearm blood flow response (FBF, ml·min 2 1 ·dl 2 1 ) to intrabrachial infusion of BHT-933 (0.5, 1, and 2 m g·min 2 1 ·dl 2 1 ) or isoproterenol (1, 3, and 6 ng...

After we reviewed our simulation results, we realize that the way we set the combined DHT/BHT table size may not have been the optimal. For simplicity, we assumed that the DHT and BHT components had the same number of table entries. We now feel that a the DHT should have more table entries than the BHT. We believe that the prediction rates will remain lower than the DHT-2 alone. The main advant...

rane (Suprane, Baxter Healthcare, Puerto Rico, USA) in the Dräger vaporizer (Dräger D-vapor, Dräger Medical GmbH, Lübeck, Germany) had turned yellow while filling the vaporizer (Fig. 1). We immediately changed the vaporizer. Yellow discoloration of desflurane occurs relatively infrequently and is not widely known; however, this was the second incident in our hospital. The yellowing of desfluran...