A plasmid vector, termed pSG5rab.gp, expressing the glycoprotein of rabies virus was tested in young adult or neonatal mice in the presence of maternally transferred immunity or passively administered antibodies to rabies virus for induction of an antibody response. Mice born to rabies virus-immune dams developed an impaired antibody response to genetic immunization at 6 weeks of age, as had be...

Perspectives Rabies – a viral zoonosis– is recognized as a priority disease for global and national level control measures. 1–3 Key interventions for rabies control include vaccination for high-risk individuals, surveillance of human cases, post-exposure prophylaxis following animal bites, vaccination and/or culling of the canine population and other animal reservoirs. Despite the known effecti...

OBJECTIVE To evaluate the effect of various routes of administration and number of doses of 3 commercially produced rabies vaccines on serum antibody responses and protection in mice challenged by intracerebral injection with fixed-strain rabies virus. ANIMALS 2,213 mice. PROCEDURE Inactivated, adjuvanted rabies vaccines were administered to mice in either 2, 1, or 0 (control) doses via IP,...

A procedure for testing inactivated rabies vaccines of tissue culture origin for residual viable virus is reported in which the vaccine to be tested is passed in primary hamster kidney cell culture (PHK) before mouse inoculation. In preliminary experiments, titrations of rabies virus in which each dilution was passed in PHK before inoculating mice yielded titers 100 to 10,000 times higher than ...

BACKGROUND Rabies is a major zoonotic viral disease and is detected using the World Health Organization standard diagnostic techniques. Rabies detection is preferably done using the fluorescent antibody technique (FAT) that provides reliable diagnosis with almost 100% accuracy for all variant strains, if a proper conjugate is used. Rabies virus nucleoprotein (NP) is the most important protein u...

Rabies, the most fatal of all infectious diseases, remains a major public health problem in developing countries, claiming the lives of an estimated 55,000 people each year. Most fatal rabies cases, with more than half of them in children, result from dog bites and occur among low-income families in Southeast Asia and Africa. Safe and efficacious vaccines are available to prevent rabies. Howeve...

Background: Rabies is a fatal but vaccine-preventable disease. Prevention of rabies in exposed individuals possible by providing them with the proper post-exposure prophylaxis. This study aims to assess compliance prophylaxis animal bite cases and factors associated it. Methods: A cross sectional was conducted between September 2022 November using predesigned, pretested proforma interview 300 p...

We describe five children who died of clinical rabies in a three month period (September to November 2011) in the Queen Elizabeth Central Hospital. From previous experience and hospital records, this number of cases is higher than expected. We are concerned that difficulty in accessing post-exposure prophylaxis (PEP) rabies vaccine may be partly responsible for this rise. We advocate: (a) promp...

Following Pasteur’s initial development of rabies vaccine, a variety of rabies vaccines were prepared from nerve tissues. Such nerve tissue vaccines (NTV) proved highly effective, but were also associated with occasional neuroparalytic reactions. The development of duck embryo vaccine (DEV), which is not prepared from nerve tissue, led to a fall in the rate of serious reactions in rabies prophy...

In most developing countries the dog remains the major transmission vector of rabies to man, despite the widespread use of parenteral vaccination. Parenteral vaccination does not, in general, achieve population immunity levels high enough to inhibit rabies transmission within the dog population. Following the demonstration that oral vaccination induced levels of population immunity sufficient t...