The crystal structure of a mutant protein of a class A beta-lactamase from Staphylococcus aureus PC1, in which Asp179 is replaced by an asparagine (P54), has been determined and refined at 2.3-A resolution (1 A = 0.1 nm). The resulting crystallographic R factor [formula: see text] are the observed and calculated structure factor amplitudes) is 0.181 for 12289 reflections with I greater than or ...

We analyze the dependence of cooperativity of the thermal denaturation transition and folding rates of globular proteins on the number of amino acid residues, N, using lattice models with side chains, off-lattice Go models, and the available experimental data. A dimensionless measure of cooperativity, Omega(c) (0 < Omega(c) < infinity), scales as Omega(c) approximately N(zeta). The results of s...

BACKGROUND We studied food consumption and nutrient intake in subjects with depressed mood, anxiety and insomnia as indices of compromised mental wellbeing. METHODS The study population consisted of 29,133 male smokers aged 50 to 69 years who entered the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in 1985-1988. This was a placebo-controlled trial to test whether supplementation wi...

The addition of solute provides an effective means to alter the stability phases in metallic materials. This is particularly true for metastable t\ensuremath{\omega} phase Ti- and Zr-based alloys; however, underlying mechanism remains inconclusive. In present work, we show that $\ensuremath{\omega}\ensuremath{\rightarrow}\ensuremath{\beta}$ phase-transformation process can be hindered stabilize...

The critical properties characterizing the formation of Floquet time crystal in prethermal phase are investigated analytically periodically driven $O(N)$ model. In particular, we focus on line separating trivial with period synchronized dynamics and absence long-range spatial order from non-trivial where is accompanied by period-doubling dynamics. vicinity line, a combination dimensional expans...

The goals of this article are to (1) provide further validation of the Glycam06 force field, specifically for its use in implicit solvent molecular dynamic (MD) simulations, and (2) to present the extension of G.N. Ramachandran's idea of plotting amino acid phi and psi angles to the glycosidic phi, psi, and omega angles formed between carbohydrates. As in traditional Ramachandran plots, these c...

This paper deals with the classical solution of following chemotaxis system generalized logistic growth and indirect signal production \begin{eqnarray} \left\{ \begin{array}{llll} & u_t=\epsilon\Delta u-\nabla\cdot(u\nabla v)+ru-\mu u^\theta,\\ 0=d_1\Delta v-\beta v+\alpha w,\\ 0=d_2\Delta w-\delta w+\gamma u \end{array} \right. \qquad(0.1)\end{eqnarray} so-called strong $W^{1, q}(\Omega)$-solu...

This paper investigates the global boundedness of semilinear attraction-repulsion chemotaxis system with nonlinear productions and logistic source: \begin{document}$ \begin{cases} u_{t} = \Delta u-\chi\nabla\cdot(u\nabla v)+\xi\nabla\cdot(u\nabla w)+u(a-bu^s), \ (x, t)\in \Omega\times (0, T), \\[6pt] v_t v+\alpha u^k-\beta v, 0 w+\gamma u^l-\delta w, t)\in\Omega\times \end{cases} $\end{document...