Estrogen receptor alpha (ERalpha)-positive breast cancers that co-express transcription factors GATA-3 and FOXA1 have a favorable prognosis. These transcription factors form an autoregulatory hormonal network that influences estrogen responsiveness and sensitivity to hormonal therapy. Disruption of this network may be a mechanism whereby ERalpha-positive breast cancers become resistant to thera...

Metastasis is a major cause of cancer-related deaths. Approximately 80% of patients with colorectal cancer develop liver metastasis and 20% develop lung metastasis. We found that at different stages of colon cancer, IFNγ secretion from peripheral blood mononuclear cells was decreased compared with healthy controls. The ribosomal S6 kinase (RSK) family of kinases has multiple cellular functions,...

Bet-hedging theory addresses how individuals should optimize fitness in varying and unpredictable environments by sacrificing mean fitness to decrease variation in fitness. So far, three main bet-hedging strategies have been described: conservative bet-hedging (play it safe), diversified bet-hedging (don’t put all eggs in one basket) and adaptive coin flipping (choose a strategy at random from ...

background and purpose: azo dyes including direct blue 71 (db71) are toxic, mutagenic and carcinogenic contaminants in effluents of industries. this study aimed to investigate the adsorption of db71 from aqueous solution onto pistachio hull waste (phw) as a low-cost adsorbent. materials and methods: a series of experiments were performed via batch adsorption technique to examine the effect of t...

of Vienna, Vienna, Austria; Floridsdorfer Allergiezentrum, Vienna, Austria. Background: Mung beans (Vigna radiata) contain 2 Bet v 1 related proteins: Vig r 1, a member of the PR-10 subfamily, and cytokinin-specific binding protein (CSBP), a protein with low sequence identity (31%) to Bet v 1. We aimed to compare Vig r 1 and CSBP to Bet v 1 regarding biochemical and immunological properties. Me...

Abstract In this study, the photocatalytic degradation of Methylene Blue was investigated using CdSe nanoparticles. nanoparticles were synthesized via a simple method and characterized by FTIR, XRD, FESEM, BET, DRS EDS techniques. The performance optimized Response Surface Methodology (RSM) under visible light. independent variables involved initial pH, MB concentration, photocatalyst dosage, i...

of Vienna, Vienna, Austria; Floridsdorfer Allergiezentrum, Vienna, Austria. Background: Mung beans (Vigna radiata) contain 2 Bet v 1 related proteins: Vig r 1, a member of the PR-10 subfamily, and cytokinin-specific binding protein (CSBP), a protein with low sequence identity (31%) to Bet v 1. We aimed to compare Vig r 1 and CSBP to Bet v 1 regarding biochemical and immunological properties. Me...

Natural killer (NK) cells play critical roles in host defense against tumors and intracellular pathogens. Various transcription factors have been reported to alter NK cell development, but the definitive transcriptional program governing this process is not well understood. Our laboratory has shown previously that the T-box transcription factors T-bet and Eomesodermin (Eomes) direct fate and fu...