A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl, thiazolyl, and oxazolyl halides were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of d...

A catalytic asymmetric alkylation of fully substituted enolates with racemic, non-activated secondary alkyl halides is described. The chiral 1,2,3-triazolium ion enables excellent diastereo- and enantiocontrol via enantiofacial discrimination of prochiral enolates and kinetic resolution of secondary halides.

A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield.

Perovskite-related materials have received increasing attention for their broad applications in photovoltaic solar cells and information technology due to their unique electrical and magnetic properties. Here we report three new antiperovskite chalco-halides: Ba3(FeS4)Cl, Ba3(FeS4)Br, and Ba3(FeSe4)Br. All of them were found to be good solar light absorbers. Remarkably, although the shortest Fe...

Vibrational sum frequency generation (VSFG) spectroscopy and molecular dynamics (MD) simulations are used to study the surface residence and organization of gas-phase methyl halide and methyl alcohol molecules adsorbed to the air/water interface, while Raman spectroscopy is used to detect the uptake of the gas-phase species into the bulk aqueous phase. Spectroscopy results reveal the presence o...

We have predicted the phase transition pressure in some alkali halides using an interatomic potential approach based on rigid ion model. This potential form represents the composite form of the inverse power dependence and exponential dependence of the repulsive energy on interionic distance. Some thermoelastic properties such as second order elastic constants have been calculated using the sam...

An efficient, general palladium catalyst for C–O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed. Use of a catalyst based on a single bulky biarylphosphine ligand L4 (RockPhos, soon to be commercially available) has expanded this chemistry to allow the transformation of a variety of heteroaryl halides, and for the first time, allows for t...

Newly synthesized tocainide analogs were tested for their state-dependent affinity and use-dependent behavior on sodium currents (INa) of adult skeletal muscle fibers by means of the Vaseline-gap voltage clamp method. The drugs had the pharmacophore amino group constrained in position alpha [N-(2,6-dimethylphenyl)pyrrolidine-2-carboxamide (To5)] or beta [N-(2,6-dimethylphenyl)pyrrolidine-3-carb...

A. S. Shawali, M. A . A bdallah , and M. E. M. Z ay ed Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt Reprint requests to Dr. A. S. Shawali. E-mail: [email protected] Z. Naturforsch. 55b, 546-552 (2000); received February 4. 2000 Ring-Chain Tautomerism. Heterocyclic Ring Transformation, 1,3,4-Thiadiazoles The synthesis and antimicrobial activity of a s...