IN THE TITLE COMPOUND [SYSTEMATIC NAME: 3-(10,10-dimethyl-anthracen-9-yl-idene)-N,N,N-trimethyl-propanaminium chlor-ide], C(21)H(26)N(+)·Cl(-), the cyclo-hexane ring adopts a chair conformation. The dihedral angle between the terminal benzene rings is 40.43 (12)°. In the crystal, ions are linked through inter-molecular N-H⋯Cl and C-H⋯Cl hydrogen bonds, forming supra-molecular layers parallel to...

Single crystals of the title salt, C21H21NH(+)·Cl(-), were isolated as a side product from the reaction involving [(C6H5CH2)3NH]2[HPO4] and Sn(CH3)3Cl in ethanol. Both the cation and the anion are situated on a threefold rotation axis. The central N atom in the cation has a slightly distorted tetra-hedral environment, with angles ranging from 107.7 to 111.16 (10)°. In the crystal, the tri-benzy...

Human toxicity High NaCl intake without corresponding intake of water can lead to hypernatremia: the ratio of sodium to water exceeds normal, and both the plasma sodium concentration and the total body sodium increase. Consequently, the balance of extracellular and intracellular osmolality is disturbed, which can result in several clinical symptoms, like excessive thirst, weakness, headache, ir...

In the title salt, C(14)H(16)N(+)·Cl(-), the complete cation and complete anion are generated by the application of mirror symmetry. The mol-ecule is nonplanar, as seen in the dihedral angle between the terminal phenyl rings [70.92 (5)°]. In the crystal, N-H⋯Cl hydrogen bonds involving both aza-nium H atoms link the ions into a zigzag supra-molecular chain along [100].

Vinyl chloride is a manufactured substance that is used to make polyvinyl chloride (PVC) plastic products, such as pipes, wire coatings, packaging materials, and cigarette filters. Because vinyl chloride usually exists in a gaseous state, the most common way of taking vinyl chloride into the human body is inhalation. People whowork at or near a facility thatmanufactures vinyl chloride and PVC p...

To examine the functional differentiation of chloride cells in the yolk-sac membrane of tilapia (Oreochromis mossambicus) embryos, we developed a 'yolk-ball' incubation system in which the yolk sac was separated from the embryonic body and subjected to incubation in vitro. The yolk-ball preparation consists of the yolk and the covering yolk-sac membrane, which contains a rich population of chlo...

Hormone-independent prostate cancer cell lines are resistant to antineoplastic drugs, this study sought to determine the usefulness of lithium chloride as an inhibitor of glycogen synthase kinase-3β to increase the cytotoxic effect of doxorubicin, etoposide or vinblastine antineoplastic drugs on DU145 cells. Combination effect was assessed by using low and IC(50) doses of drugs + lithium chlori...

Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases. Here, we use a DNA-based, fluorescent chloride reporter to measure lysosomal chloride in Caenorhabditis elegans as well as murine and human cell culture models of lysosomal diseases. We find tha...

Salt provides 2 life-essential elements: sodium and chlorine. Chloride, the ionic form of chlorine, derived exclusively from dietary absorption and constituting the most abundant anion in the human body, plays critical roles in many vital physiologic functions, from fluid retention and secretion to osmotic maintenance and pH balance. However, an often overlooked role of chloride is its function...