The yellow fever mosquito Aedes (Stegomyia) aegypti is the main vector of dengue arbovirus and other arboviruses. Dengue prevention measures for the control of A. aegypti involve mainly the use of synthetic insecticides. The constant use of insecticides has caused resistance in this mosquito. Alternative studies on plant extracts and their products have been conducted with the aim of controllin...

ÐThe essential oils from Piper capense, P. nigrum, P. guineense and P. umbellatum from S. Tome e Prõ ncipe were investigated for the ®rst time. They were analysed by GC, GC-mass spectrometry and C NMR. Monoterpene hydrocarbons were the main group of constituents in three of the samples (P. capense, P. nigrum and P. umbellatum), whereas for the other species (P. guineense) phenylpropanoid deri...

Background: Cholangiocarcinoma (CCA) is aggressive cancer arising from the malignant transformation of biliary epithelial cells. To date, surgical resection only potential option for CCA patients due to being often chemotherapy-resistant. Therefore, finding a new compound treat necessary. Previously, synthetic (±)-kusunokinin (sKU) and its derivative (bursehernin) represented cytotoxicity effec...

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Lycorine is reported to be a multifunctional compound. We previously showed that lycorine is an HCV inhibitor with strong activity. Further research on the antivirus mechanism indicated that lycorine does not affect the enzymes that are indispensable to HCV replication but suppresses the expression of Hsc70 in the host cell to limit HCV replication. However, due to the cytotoxicity and apoptosi...

Corynoline is a 1,3-benzodioxole-containing isoquinoline alkaloid isolated from Corydalis bugeana Turcz., a traditional herbal medicine. Corynoline has reportedly demonstrated multiple pharmacologic properties. Previous studies have also shown that corynoline induced cytotoxicity and inhibited cytochrome P450 (CYP) enzymes, but the mechanisms of the adverse effects remain unknown. The major obj...

The Piper betle (Tamil: vetrilai) is a glabrous climbing vine belonging to the family Piperaceae . Essential oil from vellaikodi variety of Piper betle L leaves (Piperaceae) was extracted by hydro-distillation method in a clevenger type apparatus. The essential oil thus obtained was analyzed by gas chromatography and gas chromatography – mass spectroscopy. Sixty five components were identified ...

A set of 10 4,7-dimethoxy-1,3-benzodioxole derivatives based on a lead compound previously discovered by our group, SY-1, which was isolated from Antrodia camphorata, were evaluated for their in vitro inhibitory activity on human colorectal carcinoma cells (COLO 205). Structure-activity relationship studies of the 10 compounds indicated the importance of the chain length of the alkyl group at t...