A rapid and inexpensive method has been developed to estimate rates of benzo(a)pyrene phenol production by per fused rat liver. This method is based on the measurement of benzo(a)pyrene phenols utilizing a simple fluorometric proce dure. Within 2 to 3 min after infusion of benzo(a)pyrene bound to serum albumin, phenols are excreted into the perfusate, primarily as glucuronide and sulfate conjug...

An improved high-performance liquid chromatography/fluorometric assay has been established to quantitate the benzo(«)pyrene (BP) tetrols released after acid hydrolysis of lung DN A from lung cancer patients, so that the formation of benzo(a)pyrene diol-epoxide-DNA adducts can be measured. The r-7,c-10,f-8,f-9-tetrahydroxy-7,8,9,10-tetrahydro-BP isolated by high-performance liquid chromatograph...

Polycyclic aromatic hydrocarbons (PAHs) are widespread pollutants and they can cause cancer, abnormality mutation. Nine natural PAHs-degrading bacteria were obtained from polluted areas. These the bacterial mixture degrade phenanthrene, anthracene, pyrene benzo[a]pyrene. The increase degradation rates of several PAHs compounds, such as phenanthrene benzo[a]pyrene, during repaired process, these...

2827 Heterogeneity of Strain R Avian (Erythro blastosis) Virus. 2852 Pharmacological Studies of the Antitumor Agent 6-Methylthiopurine Ribonucleoside. 2863 Cytolytic Effect of 6-Hydroxydopamine on Neuroblastoma Cells. 2881 Development of Hepatic Tumors in Rats following Ingestion of Senecio longiobus. 2898 Stimulatory Effect of Benzo(a)pyrene and Phenobarbital Pretreatment on the Biliary Ex cre...

A rapid and inexpensive method has been developed to estimate rates of benzo(a)pyrene phenol production by perfused rat liver. This method is based on the measurement of benzo(a)pyrene phenols utilizing a simple fluorometric procedure. Within 2 to 3 min after infusion of benzo(a)pyrene bound to serum albumin, phenols are excreted into the perfusate, primarily as glucuronide and sulfate conjugat...

The nal¨ve library from the lymphocytes of healthy humans was screened by murine single-stranded idiotypic antibodies against benzo[a]pyrene (pSh). The phage clone which contained of anti-idiotypic antibody against benzo[a]pyrene, designated as A4, was chosen for further work because of highly specific to pSh. The available protein databases were searched. The A4 amino acid sequence was unique ...

The oral cancer potencies of six polycyclic aromatic hydrocarbons (benzo[b]fluoranthene, benzo[j]fluoranthene, chrysene, dibenzo[a,h]pyrene, dibenzo[a,i]pyrene, and 5-methylchrysene) were estimated from cancer dose-response data obtained from animal studies. Potency estimates obtained from newborn mouse intraperitoneal (i.p.) injection studies were converted to oral equivalent potencies. The co...

An improved high-performance liquid chromatography/fluorometric assay has been established to quantitate the benzo(«)pyrene (BP) tetrols released after acid hydrolysis of lung DN A from lung cancer patients, so that the formation of benzo(a)pyrene diol-epoxide-DNA adducts can be measured. The r-7,c-10,f-8,f-9-tetrahydroxy-7,8,9,10-tetrahydro-BP isolated by high-performance liquid chromatograph...

This is a compilation of abstracts of articles identified during the preliminary toxicological evaluation of evidence on the developmental and reproductive toxicity of benzo[a]pyrene (BaP, CAS# 50-32-8). BaP is a polycyclic aromatic hydrocarbon and a component of air pollution. Polycyclic aromatic hydrocarbons are formed as a result of incomplete combustion of organic materials and are ubiquito...