The response surface metamodel is a useful sequential methodology for approximating the relationship between the input variables and the output response in computer simulation. Several strategies have been proposed to increase the accuracy of the estimation of the metamodel. In the current paper, we introduce an effective pseudo-random number (PRN) assignment strategy with Box-Behnken design to...

Hemicelluloses can be removed from wood chips prior to mechanical pulping, which would offer new feedstocks for the production of chemicals and fuels. The aim of this study was to evaluate pre-extraction to maximize pre-extraction yield, while minimizing negative impacts on wood chips. The effects of three independent process variables (NaOH charge, pre-extraction temperature, and time) on thre...

Pectin rich fruit juices need enzymatic treatment for clarification. As fruits are rich in pectin, pectinolytic treatment can efficiently reduce viscosity resulting in clarified fruit juice. Enzymatic treatment of mango pulp results in 80% recovery of total juice present in the fruit. Use of pectin degrading polygalacturonases increases both fruit juice extraction and clarification. Polygalactu...

Aqueous mixtures of glycerol and 2-hydroxypropyl-β-cyclodextrin (CD), two non-toxic eco-friendly substances, were used as a means of extracting antioxidant polyphenols from oak acorn (Quercur robur) husks. The process was optimized by implementing a central composite (Box-Behnken) experimental design and response surface methodology, taking into consideration the critical parameters (independen...

In this study the phenolic compounds piceid, resveratrol and emodin were extracted from P. cuspidatum roots using ultrasound-assisted extraction. Multiple response surface methodology was used to optimize the extraction conditions of these phenolic compounds. A three-factor and three-level Box-Behnken experimental design was employed to evaluate the effects of the operation parameters, includin...

BACKGROUND The process of meat industry produces in a large amount of wastewater that contains high levels of colour and chemical oxygen demand (COD). So they must be pretreated before their discharge into the ecological system. METHODS In this paper, enzymatic catalysis (EC) was adopted to treat the meat wastewater. RESULTS Box-Behnken design (BBD), an experimental design for response surf...