FEA is amongst best methods that help users to solve complex problems. There are fixed number of nodes in each element of the model that define the element boundaries to which boundary condition and loads can be applied. The geometry of the structure, the load applications, stress and displacement gradients can be approximated in a accurate manner, if the mesh is finer. The problem with the foo...

The neuronal voltage-gated N-type calcium channel (Ca(v)2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived ω-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared and tested using three experimental measures of calcium channel blockade. These consisted of a ¹²⁵I-ω-conotoxin GVIA displacement assay, a fluorescen...

In this paper, the effects of the restoring force device on the response of a space frame structure resting on sliding type of bearing with a restoring force device is studied. The NS component of the El Centro earthquake and harmonic ground acceleration is considered for earthquake excitation. The structure is modeled by considering six-degrees of freedom (three translations and three rotation...

This paper presents the optimization of vibrations of centrifugal pump considering fluid-structure interaction (FSI). A set of centrifugal pumps with various blade shapes were studied using FSI method, in order to investigate the transient vibration performance. The Kriging model, based on the results of the FSI simulations, was established to approximate the relationship between the geometrica...

This paper discusses the role that structural stiffness plays in context of designing adaptive structures. The focus is on load-bearing structures with displacement control. A design methodology implemented to minimize control effort by making structure as stiff possible against external loads and flexible effect actuation. rationale tested using simple analytical numerical case studies.

BACKGROUND The aim of this study was to evaluate the biomechanical behavior of anterior inferior tibiofibularis ligament (AITFL) deficient human ankle under axial loading of ankle at stance phase of gait. In order to investigate the contribution of AITFL to ankle stability, an in vitro sequential experimental setup was simulated. METHODS The measurement of posterior displacement of distal tib...

Analytical seismic response of multi-story building supported on base isolation system is investigated under real earthquake motion. The superstructure is idealized as a shear type flexible building with lateral degree-of-freedom at each floor. The force-deformation behaviour of the isolation system is modelled by the bi-linear behaviour which can be effectively used to model all isolation syst...

Multisensory-visual, vestibular and somatosensory information is integrated for appropriate postural control. The primary goal of this study was to assess somatosensory utilization during a functional motor task of unipedal postural control, in normal healthy adults. Assessing individual bias in the utilization of individual sensory contributions during postural control may help customization o...

This paper presents in-plane electrostatic comb-drive actuators with stroke as large as 245 μm that is achieved by employing a novel Clamped Paired Double Parallelogram (C-DPDP) flexure mechanism. For a given flexure beam length, comb gap, and actuation voltage, this is currently the largest comb-drive actuator stroke reported in the literature. The C-DP-DP flexure mechanism design offers high ...

The present work is concerned with the verification and validation of an implementation of the eigenfracture scheme of Schmidt et al. (SIAM J Multiscale Model Simul 7:1237–1266, 2009) based on material-point erosion, which we refer to as eigenerosion. Eigenerosion is derived from the general eigenfracture scheme by restricting the eigendeformations in a binary sense: they can be either zero, in...