This review discusses the tertiary phosphines possessing various chiral skeletons that have been used in asymmetric nucleophilic organocatalytic reactions, including annulations of allenes, alkynes, and Morita-Baylis-Hillman (MBH) acetates, carbonates, and ketenes with activated alkenes and imines, allylic substitutions of MBH acetates and carbonates, Michael additions, γ-umpolung additions, an...

The influence of metal-organic frameworks (MOFs) as additives is herein described for the reaction of n-alkyl aldehydes in the presence of methylvinylketone and triphenylphosphine. In the absence of a MOF, the expected Morita-Baylis-Hillman product, a β-hydroxy enone, is observed. In the presence of MOFs with UMCM-1 and MOF-5 topologies, the reaction is selective to Aldol-Tishchenko products, t...

The readily accessible -chlorophosphonates (OCH2CMe2CH2O)P(O)CH(Cl) C6H4-4-R [1: R=Me (a), OMe (b), Cl (c), H (d)] react with ferrocenecarboxaldehyde in the presence of NaH [Horner–Wadsworth–Emmons reaction] to give good yields of ferrocenyl substituted chlorostilbenes. The novel bis ferrocenyl butadiene C5H5FeC5H4 CH CH C(CN)CHC5H4FeC5H5 (9) as well as the ferrocenyl 2-cyano-1,3-butadienes 4-R...

The asymmetric introduction of the CF3 unit is a powerful tool for modifying pharmacokinetic properties and slowing metabolic degradation in medicinal chemistry. A catalytic enantioselective addition ?-CF3 enolates allows expeditious access to functionalized chiral building blocks with CF3-containing stereogenicity. computational studies reveal that choice ligand designed palladium-complex syst...

Formation and Reactions of Acetals and Related Species . . . . . . . . . . . . . . 1 Reactions of Glucosides and Nucleosides . . . . . . . . . . . . . . . . . . . . . . . . . 4 Reactions of Ketenes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Formation and Reactions of Nitrogen Derivatives . . . . . . . . . . . . . . . . . . . 7 Imines . . . . . . . . . . . . ...