Somatosensory thalamus and cortex in rodents contain topological representations of the facial whisker pad. The thalamic representation of a single whisker ("barreloid") is presumed to project exclusively to the cortical representation ("barrel") of the same whisker; however, it was not known when this correspondence is established during early development, nor how precise the thalamocortical p...

The thalamocortical slice is widely employed for in vitro studies of cortical circuits. This preparation was developed in order to preserve anatomical and functional connectivity between the ventrobasal thalamus and somatosensory (whisker/barrel) cortex of young mice, and thalamocortical slice experiments have contributed significantly to our understanding of the thalamocortical synapse. Cortic...

Oxygen is an important factor for the quality of wine aged in barrels. The development a tool to classify wood by its oxygen transmission rate (OTR) has made it possible use same batch make barrels that oxygenate twice as much others. Therefore, aim this study was evaluate phenolic composition and colour red twelve months with low (LOTR) high (HOTR). results showed evolves differently different...

Despite efforts for over 25 years, de novo protein design has not succeeded in achieving the TIM-barrel fold. Here we describe the computational design of four-fold symmetrical (β/α)8 barrels guided by geometrical and chemical principles. Experimental characterization of 33 designs revealed the importance of side chain-backbone hydrogen bonds for defining the strand register between repeat unit...

Sensory deprivation during a critical period reduces spine motility and disrupts receptive field structure of layer 2/3 neurons in rat barrel cortex. To determine the locus of plasticity, we used laser scanning photostimulation, allowing us to rapidly map intracortical synaptic connectivity in brain slices. Layer 2/3 neurons differed in their spatial distributions of presynaptic partners: neuro...

The postnatal ontogeny of [t25I]a-bungarotoxin (a-Btx) binding distribution in rat neocortex was described and quantified using autoradiography of in vitro labeled brain sections. During the first two weeks, distinctive transitory radial and laminar patterns emerged. Dense columnar bands of a-Btx binding extended through the depth of primary sensory cortex, including somatosensory, visual and a...

The HERMES collaboration at DESY will install a new recoil detector surrounding its target region for the envisaged final two years of the HERA II running period aiming at detecting recoiling nucleons from hard exclusive scattering [1, 2]. Protons and Pions with momenta p > 250 MeV/c will be detected and identified by a two–barrel scintillating fibre tracker (SFT). It consists of two barrels ma...