نتایج جستجو برای: bap 6

تعداد نتایج: 958687  

2008
Michelle Lawrence Steven Tannenbaum

It is believed that the formation of DNA adducts is an essential initial step in carcinogenesis. To better understand this initial step and its relationship to cancer, this study primarily focuses on benzo(a)pyrene (BaP), a highly carcinogenic model polycyclic aromatic hydrocarbon (PAH) and an ubiquitous environmental contaminant. The objective of this dissertation was to identify and quantify ...

2006
Gülgün S. Güven Mehmet Güven Ilhan Onaran Seniha Hacihanefioglu

Sister chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes has been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[ ]pyrene (BaP). We studied the ability of BaP to induce SCE and CA in 16 glutathione S-transferase M1 (GSTM1)-positive and 15 GSTM1-null individuals by analyzing 72-h whole-blood lymph...

1995
Todor Genkov Iordanka Ivanova

In the present study examined the effects of different types of cytokinins on the growth of in vitro cultured carnation. NAA alone produced neither multiplication nor elongation. Combined with BAP, NAA increased multiplication. The biological activity of 4-PU-30 and especially that of thidiazuron was considerably higher than BAP’s activity. In equal concentrations with BAP thidiazuron increased...

Journal: :IOP conference series 2021

Improved Celeste is one of the common types fig and potential to be cultivated in Indonesia. This research aimed study effect several combinations plant growth regulators on shoot induction var. Celeste. The was conducted at Tissue Culture Laboratory, Department Food Crops Horticulture, Gedung Johor, North Sumatra, Medan. using a non-factorial Completely Randomized Design (CRD) with 4 treatment...

Journal: :Archives of environmental contamination and toxicology 2003
J F McCarthy L W Burrus V R Tolbert

The accumulation of 14C-benzo(a)pyrene (BaP) sorbed to sediment was examined in fathead minnows (Pimephales promelas) to compare uptake from sediment with a high organic carbon (OC) content (7.7%), to that with a low OC content (2%). Ingestion of sediments was quantified by co-labeling the sediment with 141Cerium, which was not assimilated by the fish. Results of this study indicated that (1) s...

2016
Nikolai L. Chepelev Alexandra S. Long Wayne J. Bowers Rémi Gagné Andrew Williams Byron Kuo David H. Phillips Volker M. Arlt Paul A. White Carole L. Yauk

Benzo[a]pyrene (BaP) is a genotoxic carcinogen and a neurotoxicant. The neurotoxicity of BaP is proposed to arise from either genotoxicity leading to neuronal cell death, or perturbed expression of N-methyl-d-aspartate receptor (NMDAR) subunits. To explore these hypotheses, we profiled hippocampal gene expression of adult male Muta(™) Mouse administered 0, 1, 35, or 70 mg BaP/kg bw per day by o...

Journal: :Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001
N Kazerouni R Sinha C H Hsu A Greenberg N Rothman

Animal studies have shown that dietary intake of benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), causes increased levels of tumors at several sites, particularly in the upper gastrointestinal tract. However, the role of dietary intake of BaP and cancer in humans is not clear. We created a BaP database of selected food products that could be linked to Food Frequency Questionnaires...

2017
Marie Stiborová Radek Indra Michaela Moserová Lucie Bořek-Dohalská Petr Hodek Eva Frei Klaus Kopka Heinz H. Schmeiser Volker M. Arlt

Abstract Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP). In the previous studies, we had shown that not only the canonic NADPH:CYP oxidoreductase (POR) can act as electron donor but also cytochrome b5 and its reductase, NADH:cytochrome b5 reductase. Here, we studied the role of the expression system used on the metabol...

Journal: :Journal of cardiovascular pharmacology 2011
Mona E Aboutabl Beshay N M Zordoky Bruce D Hammock Ayman O S El-Kadi

We recently demonstrated that benzo(a)pyrene (BaP) causes cardiac hypertrophy by altering arachidonic acid metabolism through the induction of the expression of CYP ω-hydroxylases and soluble epoxide hydrolase (sEH) enzymes. The inhibition of CYP ω-hydroxylase enzymes partially reversed the BaP-induced cardiac hypertrophy. Therefore, it is important to examine whether the inhibition of sEH also...

Journal: :Pakistan journal of biological sciences : PJBS 2008
V G Omran A Bagheri N Moshtaghi

This study surveyed a rapid, efficient and reproducible protocol for in vitro shoot regeneration and rooting by different explants and different concentration of BAP. Due to optimization of shoot regeneration, two media including of MS and modified MS (MS salts with double concentration of CaC21, and B5 vitamins), different explants such as decapitated embryo axes, epicotyls and cotyledonary no...

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