Several investigators (Gratia and Jaiman, 1921; Colvin, 1932) have noted the failure of lysis of susceptible bacteria by bacteriophage in various body fluids. In studies with mycobacteriophages (White and Knight, 1959) it was shown that a factor precipitated by ammonium sulfate in the y-globulin fraction of human serum prevented propagation by mycobacteriophage D-29 on human tubercle bacilli. I...

It is believed that persistence of small populations of Mycobacterium tuberculosis in hosts underlies latent tuberculosis. Very little is known about the morphological and physiological nature of tubercle bacilli in latent TB. It is under discussion whether and how tubercle bacilli adapt to latent state and remain alive in face of damaging stressful conditions such as antibiotics and host immun...

Tubercle bacilli has been known to live in symbiosis with mankind since centuries. mainly causes pulmonary disease but extra manifestations are fairly common spine being the most site

The mechanism underlying antimicrobial activity of conjugated bile acids against strains lactic acid bacilli is not well understood. purpose this study was to investigate two typical (glycochenodeoxycholic and taurochenodeoxycholic acid) for their mechanisms four different species at the physiological pH small intestine humans. bacterial cell membrane integrity, transmembrane potential, gradien...

Carbapenems are used as antibiotics of last resort for treating Background infections due to multidrug-resistant Gram-negative bacilli, but emergence of Carbapenem resistant Gram-negative bacilli have been reported due to the production of Carbapenemase enzymes that significantly limits treatment options for life-threatening infections. : This study aimed to detect Carbapenem resistant Gram-neg...

The knowledge of the prevalence of drug resistant tuberculosis in the population is important information about the epidemiology of the disease in the country. In Poland, the incidences of drug-resistant tuberculosis have been monitored since the early years of chemotherapy. In the period from 1997 to 2012 were four prospective studies covering the whole country. The aim of this study was to de...

The detection of tubercle bacilli in the sputum is regarded by many as of unfavorable prognostic significance, regardless of the number detected and the frequency with which they are found. This study is an attempt to evaluate the prognostic significance of small numbers of tubercle bacilli detected in the sputum by concentration methods. Sputum with modified Gaffky counts of i, ii, or iii were...

I n his Opinion [1], Noel Smith questions that the Mycobacterium tuberculosis complex (MTBC) is a successful clone that emerged from a much broader and ancient mycobacterial species, whose extant representatives are Mycobacterium canettii and other smooth tubercle bacilli [2]. He suggests that our conclusion is weak because he sees it as solely based on comparison of single nucleotide polymorph...

In agreement with previous work (6) it was found that in normal rabbits after a primary inoculation of 0.01 mg. of human tubercle bacilli the organism shows a preliminary growth, which commences at once in all the organs, and reaches its height in the second week in the liver, spleen, and bone marrow; thereafter destruction begins, and is practically complete by the sixth week in the liver and ...

1. The only reliable method that can be used for the detection of tetanus bacilli is the culturing of the suspected material, the isolation of tetanus-like organisms and the demonstration that the pure cultures form a spasm-producing toxin that is neutralized by tetanus antitoxin. 2. Using this method we have demonstrated tetanus bacilli in 34.7 per cent of stools from 78 individuals in Peking....