نتایج جستجو برای: bach2
تعداد نتایج: 191 فیلتر نتایج به سال:
IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
Recent studies have advanced our understanding of the pathophysiology autoimmune gastritis, particularly its molecular aspects. The most noteworthy recent advancement lies in identification several candidate genes implicated pathogenesis pernicious anemia through genome-wide association studies. These include PTPN22, PNPT1, HLA-DQB1, and IL2RA. also directed attention towards other such as ATP4...
Clonal expansion of infected CD4+ T cells is a major mechanism HIV-1 persistence and barrier to achieving cure. Potential causes are homeostatic proliferation, effects integration, interaction with antigens. Here, we show that it possible link antigen responsiveness, the full proviral sequence, integration site, cell receptor β-chain (TCRβ) sequence examine role recurrent antigenic exposure in ...
PURPOSE Triple negative (TN) breast cancers which lack expression of the estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER2) receptors convey a poor prognosis due in part to a lack of targeted therapies. METHODS To identify viable targets for the treatment of TN disease, we have conducted a gene set enrichment analysis (GSEA) on seven different breast cancer whole gen...
Pretreatment tumor PD-L1 expression has been shown to correlate with response to anti-PD-1/PD-L1 therapies. Yet, most patients with PD-L1(+) tumors do not respond to treatment. The current study was undertaken to investigate mechanisms underlying the failure of PD-1-targeted therapies in patients with advanced renal cell carcinoma (RCC) whose tumors express PD-L1. Formalin-fixed, paraffin-embed...
There is tremendous scientific and clinical value to further improving the predictive power of autoantibodies because autoantibody-positive (AbP) children have heterogeneous rates of progression to clinical diabetes. This study explored the potential of gene expression profiles as biomarkers for risk stratification among 104 AbP subjects from the Diabetes Autoimmunity Study in the Young (DAISY)...
OBJECTIVE Glycans attached to the Fc portion of IgG are important modulators of IgG effector functions. Interindividual differences in IgG glycome composition are large and they associate strongly with different inflammatory and autoimmune diseases. IKZF1, HLA-DQ2A/B, and BACH2 genetic loci that affect IgG glycome composition show pleiotropy with systemic lupus erythematosus (SLE), indicating a...
The human beta-globin locus control region (LCR) is required to properly regulate chromatin domain opening, replication timing, and globin gene activation. The LCR contains multiple NF-E2 sites (Maf recognition elements, MAREs) that allow the binding of various basic leucine zipper (bZip) proteins like p45 NF-E2, Nrf1, Nrf2, Bach1, and Bach2, in some cases as obligate heterodimers with a small ...
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