نتایج جستجو برای: bace 1
تعداد نتایج: 2752751 فیلتر نتایج به سال:
BACKGROUND Alzheimer's disease (AD) is characterized by progressive neuronal loss and cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women even when data are adjusted for age. OBJECTIVE We set out to compare changes in 9-month-old male and female mice which overexpress amyloid precursor protein (APP) with presenilin (PS1; APP/PS1 mice) and to evaluate whet...
Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However, genetic and pharmacological evidence indicates that low brain cholesterol leads to neurodegeneration. This apparent contradiction prompted us to analyze the role of neuronal cholesterol in amyloid peptide generation in experimental syste...
The phosphotyrosine binding domain of the neuronal protein X11a/mint-1 binds to the C-terminus of amyloid precursor protein (APP) and inhibits catabolism to b-amyloid (Ab), but the mechanism of this effect is unclear. Coexpression of X11a or its PTB domain with APPswe inhibited secretion of Ab40 but not APPsbswe, suggesting inhibition of cbut not b-secretase. To further probe cleavage(s) inhibi...
The purpose of this study is to assess the extent to which locus of self (institutional versus impulse), measured using the Twenty Statements Test (TST), moderates the relationship between beliefs about alcohol and the college experience (BACE) and alcohol use among college undergraduates. Although the majority of our respondents listed more idiosyncratic personal characteristics and preference...
The beta-amyloid (Abeta) precursor protein (APP) is cleaved sequentially by beta-site of APP-cleaving enzyme (BACE) and gamma-secretase to release the Abeta peptides that accumulate in plaques in Alzheimer's disease (AD). GGA1, a member of the Golgi-localized gamma-ear-containing ARF-binding (GGA) protein family, interacts with BACE and influences its subcellular distribution. We now report tha...
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