نتایج جستجو برای: b5

تعداد نتایج: 2878  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2016
Emily E Scott C Roland Wolf Michal Otyepka Sara C Humphreys James R Reed Colin J Henderson Lesley A McLaughlin Markéta Paloncýová Veronika Navrátilová Karel Berka Pavel Anzenbacher Upendra P Dahal Carlo Barnaba James A Brozik Jeffrey P Jones D Fernando Estrada Jennifer S Laurence Ji Won Park Wayne L Backes

This symposium summary, sponsored by the ASPET, was held at Experimental Biology 2015 on March 29, 2015, in Boston, Massachusetts. The symposium focused on: 1) the interactions of cytochrome P450s (P450s) with their redox partners; and 2) the role of the lipid membrane in their orientation and stabilization. Two presentations discussed the interactions of P450s with NADPH-P450 reductase (CPR) a...

2016
Marie Stiborová Radek Indra Michaela Moserová Eva Frei Heinz H. Schmeiser Klaus Kopka David H. Philips Volker M. Arlt

Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after activation by cytochrome P450 (P450). Here, we investigated whether NADH:cytochrome b5 reductase (CBR) in the presence of cytochrome b5 can act as sole electron donor to human P450 1A1 during BaP oxidation and replace the canonical NADPH:cytochrome P450 reductase (POR) system. We also studied the efficiencies of the c...

Journal: :Clinical chemistry 1984
A Kaftory E Hegesh

A sensitive, precise enzymic/spectrophotometric method for determining cytochrome b5 in small amounts of blood is described. Mean values for healthy individuals, ages 20 to 70 years, were 0.26 (SD 0.03) mumol per liter of erythrocytes or 0.87 (SD 0.14) nmol per gram of hemoglobin. We believe the assay is preferable to methods described hitherto, primarily because of its high sensitivity.

Journal: :The Journal of clinical investigation 2002
Fredric E Wondisford

As a first-year medical student, you could count on the simplicity and elegance of the thyroid axis, because all its details had apparently been elucidated. Hypothalamic thyrotropin-releasing hormone (TRH) promoted the synthesis, release, and glycosylation of pituitary thyrotropin, thyroid-stimulating hormone (TSH), which in turn acted on the thyroid follicle, leading to the synthesis and relea...

Journal: :Neuroscience 2013
L R Zhong L Artinian V Rehder

Dopamine (DA) plays fundamental roles as a neurotransmitter and neuromodulator in the central nervous system. How DA modulates the electrical excitability of individual neurons to elicit various behaviors is of great interest in many systems. The buccal ganglion of the freshwater pond snail Helisoma trivolvis contains the neuronal circuitry for feeding and DA is known to modulate the feeding mo...

Journal: :Journal of virology 2009
Mohammed Rafii-El-Idrissi Benhnia Megan M McCausland Juan Moyron John Laudenslager Steven Granger Sandra Rickert Lilia Koriazova Ralph Kubo Shinichiro Kato Shane Crotty

Antibody neutralization is an important component of protective immunity against vaccinia virus (VACV). Two distinct virion forms, mature virion and enveloped virion (MV and EV, respectively), possess separate functions and nonoverlapping immunological properties. In this study we examined the mechanics of EV neutralization, focusing on EV protein B5 (also called B5R). We show that neutralizati...

Journal: :Biology of reproduction 2003
C J Corbin F M Moran J D Vidal J J Ford T Wise S M Mapes V C Njar A M Brodie A J Conley

Limits to estrogen production by early and late preovulatory porcine follicles were assessed by comparing enzymatic capacities for androgen (17,20-lyase) and estrogen (aromatase) synthesis in theca interna and granulosa, support of enzyme activities by the redox partner proteins NADPH-cytochrome P450 oxidoreductase (reductase) and cytochrome b5, and tissue-specific expression and regulation of ...

بیماری ساقه سیاه یکی از بیماری‌های مهم قارچی آفتابگردان است. اطلاع از نحوه توارث و کنترل ژنتیکی صفت اهمیت ویژه‌ای در انتخاب روش مناسب به‌نژادی برای مقاومت به این بیماری دارد. در این تحقیق دو ژنوتیپ ENSAT-B5 و AS613 آفتابگردان به همراه ژنوتیپ جهش یافته M5-54-1 که دارای واکنش متفاوت به جدایه­های MP8 و MP10 (قارچ عامل بیماری ساقه سیاه) بودند، انتخاب و نسل‌های F1، F2، BC1 و BC2 از طریق تلاقی‌های EN...

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