نتایج جستجو برای: b12

تعداد نتایج: 8822  

2004
Mustafa Vakur Bor Ebba Nexø Anne-Mette Hvas

Background: We evaluated whether measurement of vitamin B12-saturated transcobalamin (holo-TC) concentrations or TC saturation (holo-TC:total TC) reflects active vitamin B12 absorption in healthy individuals and patients after vitamin B12 intake. Methods: We obtained blood samples from 31 healthy individuals (age range, 25–57 years) before (days 1 and 0) and after (days 1, 2, and 6) oral admini...

Journal: :British journal of haematology 2001
Y Gielchinsky D Elstein R Green J W Miller Y Elstein N Algur A Lahad E Shinar A Abrahamov A Zimran

This study ascertained serum vitamin B12 levels among patients with Gaucher disease and among healthy Israelis. Serum B12 and metabolites' levels were studied in consecutive adult patients with Gaucher disease not treated with enzyme plus Ashkenazi Jewish neighbour-controls, together with healthy blood-donor volunteers of various ethnicities. Each group showed a high incidence of low serum B12 ...

2018
Alice Pannérec Eugenia Migliavacca Antonio De Castro Joris Michaud Sonia Karaz Laurence Goulet Serge Rezzi Tze Pin Ng Nabil Bosco Anis Larbi Jerome N. Feige

BACKGROUND Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeletal system, where vitamin B12 deficiency is generally believed to be linked to poor nutritional intake. In the present study, we asked whether ...

Journal: :Annual review of microbiology 1996
J R Roth J G Lawrence T A Bobik

This review examines deoxyadenosylcobalamin (Ado-B12) biosynthesis, transport, use, and uneven distribution among living forms. We describe how genetic analysis of enteric bacteria has contributed to these issues. Two pathways for corrin ring formation have been found-an aerobic pathway (in P. denitrificans) and an anaerobic pathway (in P. shermanii and S. typhimurium)-that differ in the point ...

2014
Donghoon Kang Jae-Seung Yun Sun-Hye Ko Tae-Seok Lim Yu-Bae Ahn Yong-Moon Park Seung-Hyun Ko Yu Wang

Long-term and high-dose treatment with metformin is known to be associated with vitamin B12 deficiency in patients with type 2 diabetes. We investigated whether the prevalence of B12 deficiency was different in patients treated with different combination of hypoglycemic agents with metformin during the same time period. A total of 394 patients with type 2 diabetes treated with metformin and sul...

2012
KW Liu DLK Dai

Objective. To compare the prevalence of the vitamin B12 deficiency in geriatric diabetic patients treated with or without metformin. Methods. Records of 134 patients with diabetes mellitus (DM) aged 61 to 93 (mean, 80) years who were treated with (n=56) or without (n=78) metformin were reviewed. Patient demographics (age, gender, duration of DM, smoking status, alcohol consumption), medication ...

2016
Paul Henry Golding

The concentration of total vitamin B12 in serum is not a sufficiently sensitive or specific indicator for the reliable diagnosis of vitamin B12 deficiency. Victor Herbert proposed a model for the staged development of vitamin B12 deficiency, in which holotranscobalamin (HoloTC) is the first indicator of deficiency. Based on this model, a commercial immunoassay has been controversially promoted ...

Journal: :Journal of breath research 2011
David A Wagner Richard Schatz Richard Coston Cheryl Curington Daniel Bolt Phillip P Toskes

Vitamin B12 deficiency is emerging as a growing public health problem. The most commonly used diagnostic tests are limited in accuracy, sensitivity, and are non-specific for B12 deficiency. The aim of this study was to develop a simple B12 breath test (BBT) to more accurately evaluate vitamin B12 status as an alternative to the most common diagnostic test, serum B12 levels. The breath test is b...

Journal: :The Journal of the American Osteopathic Association 2016
Heather Fields Barbara Ruddy Mark R Wallace Amit Shah Denise Millstine Lisa Marks

Plant foods contain a negligible amount of vitamin B12; thus, vegans have difficulty meeting the recommended daily allowance (2.4 μg) and maintaining adequate serum concentrations of B12. In a cross-sectional study of 689 men, 121 of 232 vegans (52%) were B12 deficient (<118 pmol/L), whereas only 1 of 226 omnivores (0%) was B12 deficient.15 A prospective study of 20 omnivores who adopted a vega...

Journal: :veterinary research forum 2013
esmaeal tamaddonfard1 farzad samadi karim egdami

the present study was performed to investigate the effects of long-term intraperitoneal (ip) injection of vitamin b12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. neuropathic pain was induced by crush injury in right tibial nerve. acetone spray and von frey tests were used to obtain cold and mechanical allodynia respons...

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