نتایج جستجو برای: b ketoacyl coa synthase

تعداد نتایج: 993892  

Journal: :Systems microbiology and biomanufacturing 2021

Pinene is an active natural monoterpene from plants and has important applications in flavorings, fragrances,and pesticides. Especially, pinene dimers are regarded as renewable fuels with high density. However, the microbial production was limited by low activity synthase. In this study, synthase improved fusion linker optimization chaperon coexpression. To construct pathway Saccharomyces cerev...

Journal: :Journal of bacteriology 1968
S L Marcus H C Reeves S J Ajl

Acyl carrier protein (ACP coli) was isolated from commercially grown Escherichia coli B and was acetylated by chemical methods. Biological activity of the synthesized acetyl-ACP coli was checked in an in vitro fatty acid-synthesizing system isolated from E. coli B. Since acetyl-ACP is preferred over acetyl-coenzyme A (CoA) as a substrate in these reactions, the possibility that it may substitut...

2009
Aner Gurvitz

Mycobacterium tuberculosis mtFabD is an essential malonyl-CoA:AcpM transacylase and is important for vital protein-protein interactions within type 2 fatty acid synthase FASII. mtFabD contacts KasA, KasB, FabH, InhA, and possibly also HadAB, HadBC, and FabG1/MabA. Disruption of mtFabD's interactions during FASII has been proposed for drug development. Here, the gene for a mitochondrially target...

Journal: :The Biochemical journal 1997
S H Adams C S Alho G Asins F G Hegardt P F Marrero

The low ketogenic capacity of pigs correlates with a low activity of mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase. To identify the molecular mechanism controlling such activity, we isolated the pig cDNA encoding this enzyme and analysed changes in mRNA levels and mitochondrial specific activity induced during development and starvation. Pig mitochondrial synthase showed a tis...

2017
Neža Palir Jos P. N. Ruiter Ronald J. A. Wanders Riekelt H. Houtkooper

In recent years the short-chain fatty acid, 4-phenylbutyrate (PB), has emerged as a promising drug for various clinical conditions. In fact, PB has been Food and Drug Administration-approved for urea cycle disorders since 1996. PB is more potent and less toxic than its metabolite, phenylacetate (PA), and is not just a pro-drug for PA, as was initially assumed. The metabolic pathway of PB, howev...

1997
TUNG T. HOANG

The Pseudomonas aeruginosa fabA and fabB genes, encoding b-hydroxyacyl-acyl carrier protein dehydratase and b-ketoacyl-acyl carrier protein synthase I, respectively, were cloned, sequenced, and expressed in Escherichia coli. Northern analysis demonstrated that fabA and fabB are cotranscribed and most probably form a fabAB operon. The FabA and FabB proteins were similar in size and amino acid co...

Journal: :The Biochemical journal 1968
D H Williamson M W Bates H A Krebs

1. The activities of hydroxymethylglutaryl-CoA synthase and lyase in rat liver were found to be two- to 15-fold greater than those reported by other authors under similar conditions. 2. When expressed on the basis of body weight, no appreciable differences were found between the activities of hydroxymethylglutaryl-CoA synthase in whole homogenates of livers from normal and starved rats. The syn...

Journal: :Biochemical Society transactions 1995
G Arias R Matas G Asins F G Hegardt D Serra

Hepatic ketogenesis in adult rats is controlled by two systems: i] entry of fatty acyl-CoA into mitochondria, catalyzed by carnitine palmito 1 transferase [CPT] I and 11; and ii] enzymatic activity o?mitochondrial 3-hydroxy3-methylglutaryl coenzyme A [HMG-CoA] synthase. Carnitine palmito 1 transferase [CPT] I , is a distinct rotein from C d I I . The cDNAs for both genes have gee, characterized...

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