Meiotic chromosomes in an oocyte are not only a maternal genome carrier but also provide a positional signal to induce cortical polarization and define asymmetric meiotic division of the oocyte, resulting in polar body extrusion and haploidization of the maternal genome. The meiotic chromosomes play dual function in determination of meiosis: 1) organizing a bipolar spindle formation and 2) indu...

Tissue morphogenesis requires control over cell shape changes and rearrangements. In the Drosophila mesoderm, linked epithelial cells apically constrict, without cell extrusion or intercalation, to fold the epithelium into a tube that will then undergo epithelial-to-mesenchymal transition (EMT). Apical constriction drives tissue folding or cell extrusion in different contexts, but the mechanism...

We report a new critical solution found at the threshold of axisymmetric gravitational collapse of a complex scalar field with angular momentum. To carry angular momentum the scalar field cannot be axisymmetric; however, its azimuthal dependence is defined so that the resulting stress-energy tensor and spacetime metric are axisymmetric. The critical solution found is nonspherical, discretely se...

In this article we investigate the LBB condition for axisymmetric flow problems. Specifically, the sufficiency condition for approximating pairs to satisfy the LBB condition established by Stenberg in the Cartesian coordinate setting is presented for the cylindrical coordinate setting. For the cylindrical coordinate setting, the Taylor-Hood (k = 2) and conforming Crouzeix-Raviart elements are s...

This short paper describes a numerical model study of an axisymmetric atmospheric circulation (somewhat akin to the Earth’s tropical Hadley circulation) subject to a periodic forcing that cyclically modifies the static stability. The configuration is not particularly realistic as a representation of the true circulation in the Earth’s tropics, but its motivation is justified as an idealized tes...

introduction: all instrumentation techniques have been reported to be associated with extrusion of infected debris. the aim of this study was to evaluate the number of bacteria extruded apically from extracted teeth ex vivo after canal instrumentation using the two engine-driven techniques utilizing nickel-titanium instruments (flex master and mtwo). materials and methods: seventy extracted max...

INTRODUCTION Root canal irrigation carries a risk of extrusion of irrigant into the periapical tissues. The objective of this study was to compare different irrigation systems in matched pairs of teeth prepared to an apical size of 35.06 and 50.06 by measuring the frequency and extent of apical extrusion of sodium hypochlorite (NaOCl) into a simulated periapical environment. The null hypothesis...

We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic changes and risk factors for osteoarthritis (OA) in a largely non-osteoarthritic cohort. Meniscal extrusion, tibiofemoral cartilage defect score and cartilage volume, and tibial plateau bone are...

The antiapoptotic protein Bcl-2 plays important roles in Ca(2+) signaling by influencing inositol triphosphate receptors and regulating Ca(2+)-induced Ca(2+) release. Here we investigated whether Bcl-2 affects Ca(2+) extrusion in pancreatic acinar cells. We specifically blocked the Ca(2+) pumps in the endoplasmic reticulum and assessed the rate at which the cells reduced an elevated cytosolic C...

Spine Ca 2 triggers the induction of synaptic plasticity and other adaptive neuronal responses. The amplitude and time course of Ca 2 signals specify the activation of the signaling pathways that trigger different forms of plasticity such as long-term potentiation and depression. The shapes of Ca 2 signals are determined by the dynamics of Ca 2 sources, Ca 2 buffers, and Ca 2 extrusion mechanis...