objective(s): first principles calculations were performed to study four multiple sclerosis drugs namely, ampyra, fingolimod, mitoxantrone and eliprodil in gas and liquid phases using density functional theory (dft). computational chemistry simulations were carried out to compare calculated quantum chemical parameters for ampyra, fingolimod, mitoxantrone and eliprodil. materials and methods: al...

background research predicting the public health and fiscal impact of supervised injection facilities (sifs), across different cities in canada, has reported positive results on the reduction of hiv cases among people who inject drugs (pwid). most of the existing studies have focused on the outcomes of insite, located in the vancouver downtown eastside (dtes). previous attention has not been af...

how to cite this article: ghofrani m. approach to the first unprovoked seizure- part ii. iran j child neurol. 2013 autumn; 7(4):1-5. abstract the approach to a child who has experienced a first unprovoked generalized tonic-clonic seizure is challenging and at the same time controversial. how to establish the diagnosis, ways and means of investigation and whether treatment is appropriate, are di...

the aim of this study was to determine the frequency of medication errors happened during the preparation and administration of intravenous (iv) drugs. this study was designed as prospective cross-sectional evaluations by direct unconcealed observation in a setting consisted of orthopedic, general surgery and gastroenterology wards of a teaching hospital. participants were those patients hospit...

objective: to review the potential role and specific impact of statin drugs in women with pcos. the evidence for this use of statins in pcos is limited and still under further investigation. materials and methods: a search was conducted using pubmed, dynamed and pubmedhealth databases through october 16, 2016 using the terms polycystic ovary syndrome, pcos, hydroxymethylglutaryl-coa reductase i...

abstract background: primary immunodeficiency diseases (pid) are heterogeneous group of inherited disorders mainly characterized by recurrent infections leading to several times hospital admissions. the economic impact of pid is a challenging issue; therefore, this study was designed to determine the medical costs of hospitalizations in this group of patients as an indicator of the direct cost ...

background: some antidepressant drugs can promote neuronal cell proliferation in vitro as well as hippocampal neurogenesis in human and animal models. furthermore, adipose tissue is an available source of adult stem cells with the ability to differentiate in to multiple lineages. therefore, human adipose-derived stem cells (hadscs) may be a suitable source for regenerative medical applications....

alzheimer's disease (ad) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. the exact cause of alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. this brings in mind using non-steroidal anti-inflammatory drugs (nsaid) as treatment or prevention of the dise...

for centuries, herbal drugs have been the only accessible resource for treatment of pain and passions. today, despite remarkable progress and development of synthetic drugs, medicinal plants and their derived drugs are used massively. so that, in some countries medicinal plants is inseparable from drugs and treatment systems. more ever, their marketing and economical aspects are more flourishin...

aim : the purpose of the present study was to evaluate the number and proportion of various causes of upper gastrointestinal bleeding and actual numbers of non-nsaid, non- helicobacter pylori ( h.pylori ) peptic ulcers seen in endoscopy of these patients. background : the number and the proportion of patients with non- h.pylori , non-nsaids peptic ulcer disease leading to upper gastrointestinal...