نتایج جستجو برای: avoidance memory
تعداد نتایج: 294341 فیلتر نتایج به سال:
the effect of saffranal on intracerebroventricular strepto-zotocin-induced cognitive deficits in rat
background and objective: intracerebroventricular (icv) injection of streptozotocin (stz) causes cognitive impairment in rats. the beneficial effect of saffron main component, safranal was investigated on icv stz-induced learning, memory, and cognitive impairment in male rats. materials and methods: for this purpose, rats were injected with icv stz bilaterally, on days 1 and 3 (3 mg/kg). the st...
Neuroleptics are widely prescribed drugs for the treatment of schizophrenia and related psychiatric disorders. Tardive dyskinesia (TD) is a late complication of prolonged neuroleptic treatment. Despite much research, the pathogenesis of TD remains elusive. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. Tardive dyskinesia has b...
Neuroleptics are widely prescribed drugs for the treatment of schizophrenia and related psychiatric disorders. Tardive dyskinesia (TD) is a late complication of prolonged neuroleptic treatment. Despite much research, the pathogenesis of TD remains elusive. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. Tardive dyskinesia has b...
There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...
Background: The toxic effect of sodium arsenate on nervous system has been shown; but the protective effects of several compounds against sodium arsenate are not clear. This study aimed to investigate the protective effects of nicotine and bucladesine, two positive modulators of neuronal function, on sodium arsenate toxicity against avoidance memory impairment. Methods: Male mice (N=154) were ...
Background & Aims: Diabetes mellitus is a chronic metabolic disorder that in the long-term is accompanied with deficits in learning, memory, and cognitive skills. Due to the existing evidence regarding the anti-diabetic potential of acetyl-L-carnitine (ALC), the effect of its long-term administration on learning and spatial memory deficits was investigated in diabetic rats. Methods: In this exp...
Interactions between the Cannabinoid and Nicotinic Systems in Inhibitory Avoidance Learning in Mice M. Piri [1] , M. Nasehi [2] , M.R. Zarrindast [3] Received: 09/07/09 Sent for Revision: 16/03/10 Received Revised Manuscript: 13/04/10 Accepted: 24/04/10 Background and Objective: Cannabinoid exerts have widespread and complex effects on higher cognitive functions. An overlapping di...
the central cholinergic system has been associated with cognitive function and memory and acetylcholine plays an important role during the early stages of memory consolidation. in this study, after training mice were tested with one way active avoidance procedure and retention were tested at 4, 8, 12, 16 and 24 hours of training and compared with non-shocked mice, in which it took 24 hours, a s...
اثر اولئوروپئین بر حافظۀ احترازی غیرفعال در مدل آلزایمر القاشده توسط کلشیسین در موش بزرگ آزمایشگاهی
Background and Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease along with learning and memory disorders. Oleuropein is a phenolic compound with antioxidant and neuroprotective properties that reduces oxidative stress and improves cognitive function. The purpose of this study was to investigate the effect of oleuropein pretreatment on the colchicine- induced cognit...
Background and Objective: Diabetes mellitus (DM) in long-term is associated with learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of metformin on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assign...
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