نتایج جستجو برای: avermectins

تعداد نتایج: 151  

2017
Jason D Keegan Orla M Keane Barbara Good Theo De Waal Marian Denny James P Hanrahan William Fitzgerald Maresa Sheehan

BACKGROUND Between 2013 and 2015 the Department of Agriculture, Food and the Marine (DAFM) administered a sheep technology adoption programme (STAP), with the aim of increasing profitability on Irish sheep farms by encouraging the adoption of best management practices. One of the options available to STAP participants was to test the efficacy of the anthelmintic treatment (benzimadazole, levami...

2016
Jeroen S Dickschat

As a continuation of the first two Thematic Series in the Beilstein Journal of Organic Chemistry on natural products in 2011 and 2013 [1,2], it is my pleasure to present the third issue on this topic. Natural products continue to be an inspiring field of research and an important source of potent biologically active compounds. This was recently highlighted by the fact that last year’s Nobel Pri...

Journal: :The Journal of biological chemistry 2005
Katrin Schnizler Beate Saeger Carsten Pfeffer Alexander Gerbaulet Ulrich Ebbinghaus-Kintscher Christoph Methfessel Eva-Maria Franken Klaus Raming Christian H Wetzel Arunesh Saras Hermann Pusch Hanns Hatt Günter Gisselmann

A systematic analysis of the Drosophila genome data reveals the existence of pHCl, a novel member of ligand-gated ion channel subunits. pHCl shows nearly identical similarity to glutamate-, glycine-, and histamine-gated ion channels, does however not belong to any of these ion channel types. We identified three different sites, where splicing generates multiple transcripts of the pHCl mRNA. The...

Journal: :Veterinary parasitology 2008
William J Blackhall Roger K Prichard Robin N Beech

Anthelmintic resistance in parasitic nematodes of livestock is a chronic problem in many parts of the world. Benzimidazoles are effective, broad-spectrum anthelmintics that bind to and selectively depolymerise microtubules. Resistance to the benzimidazoles, however, developed quickly and is caused by genetic changes in genes encoding beta-tubulins, subunits of microtubules. In Haemonchus contor...

2005
Francisco J. Zagmutt-Vergara Tim E. Carpenter Thomas B. Farver Ronald P. Hedrick

Sea lice infestations have become a major health problem for farmed salmonids throughout the world including Chile. In southern Chile, 6 geographical areas, divided into 22 geographical zones with a total of 127 salmon farming centers and 1519 sea pens, were regularly sampled from December 1999 to April 2002. A linear mixed-effects model (LME) approach was used to describe the infestations of a...

Journal: :Toxicology in vitro : an international journal published in association with BIBRA 2013
Marcos A Maioli Hyllana C D de Medeiros Marieli Guelfi Vitor Trinca Flávia T V Pereira Fábio E Mingatto

Abamectin (ABA), which belongs to the family of avermectins, is used as a parasiticide; however, ABA poisoning can impair liver function. In a previous study using isolated rat liver mitochondria, we observed that ABA inhibited the activity of adenine nucleotide translocator and FoF1-ATPase. The aim of this study was to characterize the mechanism of ABA toxicity in isolated rat hepatocytes and ...

2017
Young-Ran Lim Songhee Han Joo-Hwan Kim Hyoung-Goo Park Ga-Young Lee Thien-Kim Le Chul-Ho Yun Donghak Kim

Streptomyces avermitilis produces clinically useful drugs such as avermectins and oligomycins. Its genome contains approximately 33 cytochrome P450 genes and they seem to play important roles in the biosynthesis of many secondary metabolites. The SAV_7130 gene from S. avermitilis encodes CYP158A3. The amino acid sequence of this enzyme has high similarity with that of CYP158A2, a biflaviolin sy...

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