BACKGROUND Since the introduction of the orphan drugs legislation in Europe, it has been suggested that the general method of assessing drugs for reimbursement is not necessarily suitable for orphan drugs. The National Institute for Health and Clinical Excellence indicated that several criteria other than cost and efficacy could be considered in reimbursement decisions for orphan drugs. This st...

BACKGROUND Quality end-of-life care depends on understanding patients' end-of-life choices. Individuals and cultures may hold end-of-life priorities at different hierarchy. Forced ranking rather than independent rating, and by-person factor analysis rather than averaging may reveal otherwise masked typologies. METHODS We explored Saudi males' forced-ranked, end-of-life priorities and dis-prio...

how to cite this article: imanzadeh f. gastrointestinal symptoms in lysosmal disease. iran j child neurol autumn 2012; 6:4 (suppl. 1):17-18. pls see pdf.   references: 1. semenza  gl,  pyeritz  re.  respiratory complications of mucopolysaccharide storage disorders. medicine (baltimore) 1988; 67:209. 2.   wraith   je,   scarpa   m,   beck   m,   et   al. mucopolysaccharidosis type ii (hunter syn...

Itai and Rodeh showed that, on the average, the communication of a leader election algorithm takes no more than $LN$ bits, where $L \simeq 2.441716$ and $N$ denotes the size of the ring. We give a precise asymptotic analysis of the average number of rounds M(n) required by the algorithm, proving for example that $\dis M(\infty) := \lim\_{n\to \infty} M(n) = 2.441715879...$, where $n$ is the num...

PURPOSE To assess removable denture patient awareness, expectations, and source of information about dental implants (DIs). MATERIALS AND METHODS Three hundred patients [150 removable partial denture (RPD) wearers and 150 complete denture wearers (CDWs)] attended the removable prosthodontic clinic at Faculty of Dentistry, Jordan University of Science and Technology. Patients were evaluated us...

OBJECTIVE To examine demographic and clinical determinants of seeking help for mental or emotional problems. To determine the proportion of those people with a disorder who sought help. To determine what categories of professionals are sought by those who get care. METHOD A 2-stage random sample of 3956 adult residents of Edmonton, Alberta, Canada was interviewed by trained lay interviewers u...

The shapes of jets with transverse energies, E jet T , up to 45 GeV produced in neutral-current(NC) and charged-current (CC) deep inelastic e + p scattering (DIS) at Q 2 > 100 GeV 2 have been measured with the ZEUS detector at HERA. Jets are identiied using a cone algorithm in the ? ' plane with a cone radius of one unit. The jets become narrower as E jet T increases. The jet shapes in NC and C...