Objective: Autologous chondrocyte transplantation has become an established therapy for full-thickness cartilage defects. Cell-seeded collagen matrix–supported autologous chondrocyte transplantation (ACT-CS) has been introduced as a modification of conventional ACT, which allows easier handling and is intended to combine the advantages of using a cell suspension (i.e., cell viability and mitoti...

Defects in knee articular cartilage (AC) can cause pain and disability and present the clinician with an extremely challenging clinical situation. This article describes the most up-to-date surgical techniques that aim to repair and/or regenerate symptomatic focal defects in AC, which include arthroscopic debridement, microfracture bone marrow stimulation and autologous osteochondral allografti...

OBJECTIVE Autologous chondrocyte transplantation has become an established therapy for full-thickness cartilage defects. Cell-seeded collagen matrix-supported autologous chondrocyte transplantation (ACT-CS) has been introduced as a modification of conventional ACT, which allows easier handling and is intended to combine the advantages of using a cell suspension (i.e., cell viability and mitotic...

Objective: Autologous matrix-induced chondrogenesis (AMIC) is a 1-step cartilage restoration technique that combines microfracture with the use of an exogenous scaffold. This matrix covers and mechanically stabilizes the clot. There have been an increasing number of studies performed related to the AMIC technique and an update of its use and results is warranted. Design and methods: Using the P...

Osteochondral lesions of the talus occur with relatively frequency, often as sequelae benign ankle sprains, and are only surpassed by knee elbow more common locations. While microfracture is most first-line surgical treatment performed at time arthroscopy, marrow stimulation alone results in fibrocartilaginous repair tissue rather than true hyaline-like articular cartilage. In addition, benefit...

Complete excision of a neoplastic lesion on the pinna of the ear may affect the cartilaginous skeleton of this structure (Fig. 1). In contrast to the situation with other facial structures, surgery to the ear has few functional repercussions. However, cosmetic changes due to scar retraction during the healing process are common. Substitution of the cartilage is possible using alloplastic materi...

Articular cartilage does not heal spontaneously due to its limited healing capacity, and thus effective treatments for cartilage injuries has remained challenging. Since the first report by Brittberg et al. in 1994, autologous chondrocyte implantation (ACI) has been introduced into the clinic. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell (MSC)-based therapy h...

INTRODUCTION Soccer is the most popular sport worldwide with about 200 million currently registered active players.1 The frequency of soccer injuries is estimated at 10-35 per 1000 hours of competition, with the majority occurring in the lower extremities. Knee injuries account for 15-40% of soccer-related injuries.2,3 While numerous studies have described injuries of the cruciate ligaments and...

This review traces the genealogy of the field of articular cartilage repair from its earliest attempts to its present day vast proliferation of research advances. Prior to the 1980s there was only sporadic efforts to regenerate articular cartilage as it was considered to be incapable of regeneration based on historical dogma. The first flurry of reports documented the use of various cell types ...