Background: We conducted a study in order to determine the usefulness and diagnostic value of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune hepatitis (AIH) hepatic disorders as well as in AIH/ overlap syndromes and in cases with coexistence of AIH and other liver diseases. Methods: We applied the IAHG score in 423 patients with liver diseases excluding patients with AI...

Liver disease in HIV-infected patients is complex and multifactorial. Drug toxicity and infections are common causes of elevations in liver-associated enzymes. Immune reconstitution and unmasking of autoimmune disease may also play a role, particularly in the era of effective combination antiretroviral therapy. In this case report, we describe the first reported biopsy-confirmed case of autoimm...

Introduction Autoimmune hepatits (AIH) is characterized by increased liver enzymes, hypergammaglobulinemia, specific autoantibodies and typical hystologic findings. Extrahepatic autoimmune phenomena may coexist with type 1 AIH. Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease associated with the production of autoantibodies. Although it has the potential to affect ...

References GREEN, K.C. & MARGARETZ, G. (1967) Long-term follow-up of multicentre trial of ethyl-a-p-chlorphenoxyisobutyrate (Clofibrate, 'Atromnid'-S) and Clofibrate Plus Androsterone ('Atromid'). Progress in Biochemical Pharmacology, 2, 378. KATSILAMBROS, BRAATEN, J.B., FERGUSON, D. & BRADLEY, R.F. (1972) Muscular syndrome after clofibrate. New England Journal of Medicine, 286, 1 10. LANGER, T...

Autoimmune hepatitis (AIH) is a complex liver disease of unknown cause which results in immune-mediated liver injury with varied clinical presentations. Seronegative AIH follows a similar course to autoantibody-positive disease and diagnosis may be challenging. There are no single serologic tests of sufficient diagnostic specificity, and delay in appropriate treatment may lead to progression of...

Liver disease is the leading cause of non-AIDS related morbidity and mortality in human immunodeficiency virus (HIV) infected patients. There are many causes of liver disease in these patients, most commonly co-infection with viral hepatitis or alcoholic liver disease. A far less commonly described entity is autoimmune hepatitis (AIH) in HIV patients. The relationship between HIV and autoimmune...

Inflammatory Disorders Volume 4 • Issue 4 • 1000161 J Clin Cell Immunol ISSN: 2155-9899 JCCI, an open access journal *Corresponding author: Marina G Silveira, Division of Gastroenterology and Hepatology, Case Western Reserve University, Louis Stokes Cleveland VA Medical Center and Case Medical Center, 10701 East Blvd 111E (W), Cleveland, OH, 44106, USA, Tel: (216) 707-6496; Fax: (216) 231-3447;...

Forty-two patients with autoimmune liver disease have been investigated. Renal tubular acidosis was detected in 60% of the patients with primary biliary cirrhosis, in 30% with active chronic hepatitis, and in one out of seven cases with cryptogenic cirrhosis. The presence of the defect of renal acidification was not related to the level of plasma potassium, copper, or total globulin, nor to the...

BACKGROUND Autoimmune liver disease (AILD) encompasses 3 main distinct clinical diseases: autoimmune hepatitis, primary biliary cholangitis (formally known as cirrhosis, PBC) and primary sclerosing cholangitis (PSC). These conditions are an important, yet under-appreciated cause of patient morbidity and mortality with ongoing unmet needs for further research and clinical advances. KEY MESSAGE...