The immune system is the body’s main line of defense against invasion by infectious organisms, such as bacteria, virus, and fungi. In normal immune systems, an immune response does not occur against the self-antigen, and is called self-tolerance. Autoimmune diseases occur when body tissues are attacked by the body’s own immune system due to loss of tolerance to self-antigens (Dejaco et al., 200...

Conventional pretransfusion testing based on hemagglutination assays can be challenging for patients with autoimmune hemolytic anemia (AIHA) because of the presence of auto-antibodies. It has been suggested that deoxyribonucleic acid-based methods could be more efficient in the selection of antigen-matched red blood cell units in those settings. Because of the high risk of alloimmunization of t...

Interleukin-10 (IL-10)–treated dendritic cells (DCs) induce an alloantigenor peptide-specific anergy in various CD41 and CD81 T-cell populations. In the present study, we analyzed whether these anergic T cells are able to regulate antigenspecific immunity. Coculture experiments revealed that alloantigen-specific anergic CD41 and CD81 T cells suppressed proliferation of syngeneic T cells in a do...

Antigen specific immunotherapy mediated via the sustained generation of regulatory T cells arguably represents the ideal therapeutic approach to preventing beta cell destruction in type 1 diabetes. However, there is a need to enhance the efficacy of this approach to achieve disease modification in man. Previous studies suggest that prolonged expression of self-antigen in skin in a non-inflammat...

background: hydatidosis is one of the cosmopolitan parasitic zoonoses caused by the larval stage of echinococcus granulosus. diagnosis of hydatidosis is still an unresolved problem. serological tests using crude antigens for diagnosis of e. granulosus are sensi-tive, however their specificity are not satisfactory. therefore, who recommended spe-cific serological methods using specific antigens,...

objective(s): the aim of this study was to estimate effects of hyperbaric (hb) treatment by determination of cd15s and cd11b leukocyte proinflammatory markers expression.  in addition, this study describes changes in cd77 and cd34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. materials and methods:expression of cd11b and cd...