Autoimmune hepatitis is defined as chronic liver disease of unknown aetiology with aberrant auto-reactivity and genetic predisposition, characterized by female predominance, circulating auto-antibodies, hypergammaglobulinemia and association with HLA DR3 and HLA DR4. We present two patients with autoimmune hepatitis. The first patient is a young lady who was diagnosed with autoimmune chronic he...

In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular transcriptomic imprints of pathological linked autoreactive cells at single-cell resolution. We show that excessive plasmablast expansions ar...

The purpose of the study is to evaluate extent involvement spinal cord on MRI in patients with clinical diagnosis transverse myelitis. Initial assessment meticulous history important as it provides adequate information clinician Auto antibodies testing usually takes long time. Hence detailed history, Clinical features, imaging findings play vital role.

The recent U.S. FDA approval of monoclonal antibodies against CTLA4 (ipilimumab) and PD1 (nivolumab and pembrolizumab), together with the increasing number of clinical trials for new immune-checkpoint blockade antibodies in monotherapy and in combinations, have emphasized the therapeutic potential of using immunomodulatory antibodies to elicit an effective protective immunity for cancer immunot...

Intradermal injection of autologous serum and plasma elicit a cutaneous reactivity in almost 45-60% of patients with Chronic Idiopathic Urticaria (CIU). This reactivity is associated with the presence of auto antibodies against IgE or IgE receptors. This study was carried out to compare the cutaneous reactivity of autologous serum and plasma skin tests in a series of patients with CIU for diagn...

In animal experimental models, parasitic helminth infections can protect the host from auto-immune diseases. We conducted a population-scale human study investigating the relationship between helminth parasitism and auto-reactive antibodies and the subsequent effect of anti-helminthic treatment on this relationship. Levels of antinuclear antibodies (ANA) and plasma IL-10 were measured by enzyme...