Autism is a neurodevelopmental disorder currently affecting as many as 1 out of 166 children in the United States. Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation and gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, neurotransmitter abnormalities, impaired detoxification of tox...

The saccadic eye movements, generated during a visual oddball task, of autistic children, normal children, children with attention deficit disorder and hyperactivity (ADDH), and dyslexic children were examined to determine whether autistic children differed from these other groups in saccadic frequency. Autistic children made more saccades during the presentation of frequent stimuli (than norma...

An empirically based 78 question self-rating scale based on DSM-IV-TR and ICD-10 criteria was developed to assist clinicians' diagnosis of adults with autism and Asperger's Disorder-the Ritvo Autism and Asperger's Diagnostic Scale (RAADS). It was standardized on 17 autistic and 20 Asperger's Disorder and 57 comparison subjects. Both autistic and Asperger's groups scored significantly higher tha...

OBJECTIVES This article reviews the present literature on the issues encountered while coping with children with autistic spectrum disorder from the dental perspective. The autistic patient profile and external factors affecting the oral health status of this patient population are discussed upon the existing body of evidence. MATERIAL AND METHODS The MEDLINE database was searched using the t...

Autism is a neurodevelopmental disorder and this disorder shows impairment in reciprocal social interactions, deficits in communication, and restrictive and repetitive patterns of behaviors and interests. The effect of music on short-term memory in the view of cell proliferation in the hippocampus was evaluated using valproic acid-induced autistic rat pups. Animal model of autism was made by su...

OBJECTIVES To analyze cooccurring disorders and problems in a representative group of 198 preschool children with autism spectrum disorders (ASD) who had had interventions at a specialized habilitation center. METHODS Parents and children were seen by a research team. Data were based on parental interviews, pediatric assessments, and tests of the child. Information on autistic symptoms, gener...

Background: Autism is a neurological disorder that limits communication, socialization, and participation of children in symbolic play. Sensory processing disorders are common characteristics (45% to 96%) of children with pervasive development disorders, including. Sleep disorders are also more prevalent in autistic children than in normal children. Objectives: This study aimed to investigate t...

This article reviews epidemiological studies of autism and related disorders. Study designs and sample characteristics are summarized. Currently, conservative prevalence estimates are: 13/10000 for autistic disorder, 21/10000 for pervasive developmental disorders not otherwise specified, 2.6/10000 for Asperger disorder, and 2/100000 for childhood disintegrative disorder. Newer surveys suggest t...

Background: Twin, family, and linkage studies have indicated that attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) share a portion of their heritable etiology. This suggests that individuals with ADHD may manifest different forms of ASDs that may range from fully developed syndromic forms of the disorder to milder manifestations of ASD symptomatology, which w...

OBJECTIVE Autism/autistic disorder (MIM number 209850) is a complex, largely genetic psychiatric disorder. The authors recently mapped a susceptibility locus for autism to chromosome region 2q24-q33 (MIM number 606053). In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region. METHOD Mutation screening of positional candid...