We discuss how statistical inference techniques can be applied in the context of designing novel biological systems. Bayesian techniques have found widespread application and acceptance in the systems biology community, where they are used for both parameter estimation and model selection. Here we show that the same approaches can also be used in order to engineer synthetic biological systems b...

Let α = −2+ √ −1 be a root of the polynomial p(x) = x +4x+5. It is well-known that the pair (α, {0, 1, 2, 3, 4}) forms a canonical number system, i.e., that each γ ∈ Z[α] admits a finite representation of the shape γ = a0 + a1α+ · · ·+ alα with ai ∈ {0, 1, 2, 3, 4}. The set T of points with integer part 0 in this number system

We propose a likelihood function endowed with a penalisation that reduces the bias of the maximum likelihood estimator in regular parametric models. The penalisation hinges on the first two derivatives of the log likelihood and can be computed numerically. The asymptotic properties and the sensitivity to nuisance parameters of the penalised likelihood and derived quantities are addressed. In mo...

Nowadays ICT is the integral part of modern teacher’s and scholar’s activity. For teachers it is reasonable to allocate two basic approach of ICT use: e-learning courses designing (to satisfaction of educational needs of students and implementation of new educational approaches) and openness in the presentation of their own research interests. For effective implementation of these approaches it...

and Applied Analysis 3 where n α 1, α denotes the integer part of number α, provided that the right side is pointwise defined on 0, ∞ . Definition 2.2 see 20 . The Riemann-Liouville fractional integral of order α > 0 of a function f : 0, ∞ → R is given by I 0 f t 1 Γ α ∫ t 0 t − s α−1f s ds, 2.2 provided that the right side is pointwise defined on 0, ∞ . From the definition of the Riemann-Liouv...

This paper presents an unsupervised discretization method that performs density estimation for univariate data. The subintervals that the discretization produces can be used as the bins of a histogram. Histograms are a very simple and broadly understood means for displaying data, and our method automatically adapts bin widths to the data. It uses the log-likelihood as the scoring function to se...

In this paper we address the issue of research communities in science and engineering and their effects on graduate students and women in particular. We present our observations of graduate student experiences in one particular research community. These observations are considered in the context of research done by national science institutes and feminist theorists about the under-representatio...

Exegesis that includes careful attention to internal matters-theme and development, structure, and features of literary style--can help resolve perennial problems of interpretation. One such difficulty involves the unity and authorship of the book of Nahum. Conclusions reached from the shared contributions of biblical and literary data argue strongly for the unity of the whole prophecy that bea...

Consistent product experience requires congruity between product properties such as visual appearance and sound. Therefore, for designing appropriate product sounds by manipulating their spectral-temporal structure, product sounds should preferably not be considered in isolation but as an integral part of the main product concept. Because visual aspects of a product are considered to dominate t...